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Huihui Wei et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 52-57 (2014-10-02)
Clevidipine, a vascular selective calcium channel antagonist of the dihydropyridine class, is rapidly metabolized by ester hydrolysis because of incorporation of an ester linkage into the drug molecule. To characterize its pharmacokinetic profiles in dogs, a simple, rapid and sensitive
María Guadalupe Valle-Dorado et al.
Neuropharmacology, 92, 49-55 (2015-01-13)
Experiments were designed to evaluate changes in the histamine release, mast cell number and neuronal damage in hippocampus induced by status epilepticus. We also evaluated if sodium cromoglycate, a stabilizer of mast cells with a possible stabilizing effect on the
Jun Cheng et al.
Food chemistry, 168, 90-99 (2014-08-31)
The aim of this study was to investigate the applicability of artificial neural network (ANN) and multiple linear regression (MLR) models for the estimation of acrylamide reduction by flavonoids, using multiple antioxidant capacities of Maillard reaction products as variables via
Xin-Guang Liu et al.
Journal of chromatography. A, 1388, 251-258 (2015-03-03)
Hydrolysis plays an important role in the metabolic transformations of lactones. Analysis of lactones and their hydrolyzed metabolites in biological samples is challenging, because unexpected hydrolysis or reversed dehydration may occur depending on the test environments. In this work, a
Zheng Wang et al.
Applied and environmental microbiology, 81(2), 699-712 (2014-11-16)
Biocathode extracellular electron transfer (EET) may be exploited for biotechnology applications, including microbially mediated O2 reduction in microbial fuel cells and microbial electrosynthesis. However, biocathode mechanistic studies needed to improve or engineer functionality have been limited to a few select
Ida Fejős et al.
Journal of pharmaceutical and biomedical analysis, 98, 327-333 (2014-07-06)
Due to their popularity, medicinal products containing the phophodiesterase type 5 enzyme (PDE-5) inhibitors sildenafil, vardenafil and tadalafil are often subject to counterfeiting. In addition, illicit herbal dietary supplements adulterated with these substances or their analogs have appeared on the
Khemraj Bairwa et al.
Phytochemical analysis : PCA, 25(5), 415-420 (2014-03-29)
Boerhaavia diffusa is a perennial herb belonging to Nyctaginaceae. Various classes of chemical constituents such as phenolics (boeravinones), terpenoids and organic acids have been reported in B. diffusa roots. As boeravinones have been proposed as putative active constituents for the
Kang Mo Ku et al.
Journal of the science of food and agriculture, 94(10), 2090-2096 (2013-12-18)
Spray treatment of methyl jasmonate (MeJA) has been shown to increase glucosinolate (GS) concentrations and health-promoting activity in Brassica vegetables. Since there is no reported standardized protocol, several MeJA treatment studies have been conducted to maximize human health bioactivity using
Xinhuan Wan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 95-100 (2014-08-30)
A simple, rapid and sensitive reversed-phase ultra-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the simultaneous quantitative determination of oxiracetam and its degraded substance 4-hydroxy-2-oxo-1-pyrrolidine acetic acid (HOPAA) in rat plasma. After plasma samples were deproteinized
Lei Wang et al.
Environment international, 78, 45-50 (2015-03-10)
The extensive use of environmental phenols (e.g., bisphenol A) and heterocyclic aromatic compounds (e.g., benzothiazole) in consumer products as well as widespread exposure of humans to these compounds have been well documented. Biomonitoring studies have used urinary measurements to assess
Rokhsana Yasmin et al.
Journal of pharmaceutical sciences, 103(9), 2950-2959 (2014-03-04)
Lyophilization was investigated to produce a powdery silica-lipid hybrid (SLH) carrier for oral delivery of poorly water-soluble drugs. The silica to lipid ratio, incorporation of cryoprotectant, and lipid loading level were investigated as performance indicators for lyophilized SLH carriers. Celecoxib
Marcos Tascon et al.
Analytical and bioanalytical chemistry, 407(13), 3637-3645 (2015-03-10)
The use of algae as a foodstuff is rapidly expanding worldwide from the East Asian countries, where they are also used for medical care. Harmala alkaloids (HAlk) are a family of bioactive compounds found in the extracts of some plants
Tae-kyung Kwak et al.
BMC complementary and alternative medicine, 14, 419-419 (2014-10-28)
Osteopontin (OPN) is one of important molecular targets in cancer progression, metastasis as a calcium-binding, extracellular-matrix-associated protein of the small integrin-binding ligand and, N-linked glycoprotein. In the present study, anti-metastatic mechanism of ethanol extracts of Ocimum sanctum (EEOS) was elucidated
Mengting Yang et al.
Environmental science & technology, 48(20), 11846-11852 (2014-09-23)
Utilizing seawater for toilet flushing is an effective way to conserve freshwater in coastal cities. During chlorination for disinfecting saline wastewater effluents, the high levels of bromide from seawater are oxidized to hypobromous acid which may then react with effluent
Elina Makarova et al.
Journal of the science of food and agriculture, 95(3), 560-568 (2014-06-12)
The health-promoting properties of apples are directly related to the biologically active compounds that they contain, such as polyphenols. The objective of this study was to prepare a low-sugar, fibre- and phlorizin-enriched powder from unripe apples and to gain insight
Jun Yang et al.
Molecular endocrinology (Baltimore, Md.), 28(9), 1571-1584 (2014-07-08)
The mineralocorticoid receptor (MR) plays a central role in salt and water homeostasis via the kidney; however, inappropriate activation of the MR in the heart can lead to heart failure. A selective MR modulator that antagonizes MR signaling in the
Davy Baudelet et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 35-43 (2015-02-24)
The P2X receptors are seven-transmembrane domain G protein-coupled receptors and the 7 subtypes of P2X receptors identified in humans, and named P2X1 to P2X7, are channel receptors whose endogenous ligand is ATP. New antagonists of the P2X7 receptor were developed
Ilaria Naldi et al.
PloS one, 9(5), e98101-e98101 (2014-05-24)
Epigenetic events are critical contributors to the pathogenesis of cancer, and targeting epigenetic mechanisms represents a novel strategy in anticancer therapy. Classic demethylating agents, such as 5-Aza-2'-deoxycytidine (Decitabine), hold the potential for reprograming somatic cancer cells demonstrating high therapeutic efficacy
Rosaiah Kotikalapudi et al.
Pakistan journal of biological sciences : PJBS, 16(23), 1823-1825 (2014-02-11)
The aim of the study is to standardize the simple method for extracting DNA from cells fixed in fixative (3:1 ratio of methanol and acetic acid glacial) mostly used for chromosomal studies in cattle and buffaloes. These fixed cells were
Tamyris Regina Matos Lopes et al.
Pharmaceutical biology, 53(6), 897-903 (2014-11-29)
Eupatorium triplinerve Vahl (Asteraceae), popularly known as Japana, is widely used in folk medicine, due its analgesic, anticoagulant, antianorexic, antiparasitic, anthelmintic, sedative, antifungal, and antibacterial properties. The present study evaluated the chemical composition and antimicrobial activity of E. triplinerve extracts
Shuichi Toyouchi et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(17), 3832-3838 (2014-09-13)
The effect of solute affinity on solute diffusion in binary liquids well below the lower critical solution temperature (LCST) was studied by using fluorescence correlation spectroscopy. We measured the hydrodynamic radii of a hydrophobic and an amphiphilic fluorescent dye under
Stefan Hausmann et al.
PloS one, 10(4), e0122689-e0122689 (2015-04-04)
Multiple myeloma (MM) is a generally fatal plasma cell cancer that often shows activation of the phosphoinositide 3-kinase/Akt (PI3K/Akt) pathway. Targeted pharmacologic therapies, however, have not yet progressed beyond the clinical trial stage, and given the complexity of the PI3K/Akt
Jacqueline M Cole et al.
Physical chemistry chemical physics : PCCP, 16(48), 26684-26690 (2014-07-12)
A major deficit in suitable dyes is stifling progress in the dye-sensitised solar cell (DSC) industry. Materials discovery strategies have afforded numerous new dyes; yet, corresponding solution-based DSC device performance has little improved upon 11% efficiency, achieved using the N719
Rahul Banerjee et al.
Nature, 518(7539), 431-434 (2015-01-22)
Methane monooxygenase (MMO) catalyses the O2-dependent conversion of methane to methanol in methanotrophic bacteria, thereby preventing the atmospheric egress of approximately one billion tons of this potent greenhouse gas annually. The key reaction cycle intermediate of the soluble form of
Lidia Zapała et al.
Journal of solution chemistry, 43, 1167-1183 (2014-07-30)
The acid-base chemistry of three zwitterionic compounds, namely anthranilic (2-aminobenzoic acid)
Wei Liu et al.
Journal of pharmaceutical and biomedical analysis, 94, 215-220 (2014-03-19)
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are legitimate therapeutic targets for Alzheimer's disease. The classical approach for screening potential AChE/BChE inhibitors was developed by Ellman. However, the background color of compounds or plant extracts remained uncertain and frequently interfered with the
Ali Es-Haghi et al.
Talanta, 128, 231-236 (2014-07-26)
Sol-gel based solid-phase microextraction fibers supported by a stainless steel wire were fabricated and employed for GC-MS determination of oxadiargyl in real samples. The fibers were based on four compounds with different polarity: polar and non-polar (end-capped) poly(dimethylsiloxane) (PDMS), polyethylene
Vijayashankar Nataraj et al.
PloS one, 10(3), e0122804-e0122804 (2015-04-22)
Lipooligosaccharides are glycolipids found in the cell wall of many mycobacterial species including the opportunistic pathogen Mycobacterium kansasii. The genome of M. kansasii ATCC12478 contains a cluster with genes orthologous to Mycobacterium marinum LOS biosynthesis genes. To initiate a genetic
Li Ying Liu et al.
International journal of oncology, 45(3), 1257-1265 (2014-06-28)
MicroRNA (miRNA)-126 (miR-126) was reported to be downregulated and to act as a tumor suppressor in cancers of the lung, cervix, bladder and prostate. However, the functions of miR-126 in gastric cancer appear to be diverse and are largely unknown.
Rosario Caruso et al.
Natural product communications, 6(12), 1939-1943 (2012-02-09)
The influence of the wine distillation process on methanol content has been determined by quantitative analysis using gas chromatographic flame ionization (GC-FID) detection. A comparative study between direct injection of diluted wine and injection of distilled wine was performed. The
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