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Jonathan Sagal et al.
Stem cells translational medicine, 3(8), 888-898 (2014-06-07)
Human pluripotent stem cells (PSCs) are a promising cell resource for various applications in regenerative medicine. Highly efficient approaches that differentiate human PSCs into functional lineage-specific neurons are critical for modeling neurological disorders and testing potential therapies. Proneural transcription factors...
Harmeet S Sandhu et al.
Bioorganic & medicinal chemistry, 18(15), 5626-5633 (2010-07-14)
A series of arylidene analogues of Meldrum's acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The influence of various physico-chemical parameters such as dielectric constant (epsilon), donor number (DN), acceptor number (AN)...
Heinz-Dieter Müller et al.
Journal of endodontics, 41(11), 1852-1861 (2015-09-24)
Proangiogenic prolyl hydroxylase (PHD) inhibitors represent a novel approach to stimulate tissue regeneration. Diabetes mellitus involves the accumulation of advanced glycation end products (AGEs). Here we evaluated the impact of AGEs on the response of human pulp tissue to the...
Bruno Bosch Volpe et al.
Cytotherapy, 16(12), 1709-1719 (2014-10-13)
Surgical treatment for enterocutaneous fistulas (EF) frequently fails. Cell therapy may represent a new approach to treatment. Mesenchymal stromal cells (MSCs) have high proliferative and differentiation capacity. This study aimed to investigate whether MSCs could adhere to suture filament (SF)...
Emre Menteşe et al.
Journal of enzyme inhibition and medicinal chemistry, 30(3), 435-441 (2014-09-10)
Various triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings (3-6) were synthesized and screened for their antioxidant activities. The structures of the synthesized compounds (2-6) were judged by (1)H NMR, (13)C NMR, elemental analysis, and LC-MS spectral data. Antioxidant activities...
Wan Yong Ho et al.
Pakistan journal of pharmaceutical sciences, 28(1), 15-22 (2015-01-03)
Vernonia amygdalina is a strong natural antioxidant that possessed various medicinal properties. In this study, the spray-dried water extract of V. amygdalina was evaluated for its in vitro antioxidant capacity and in vivo hepatoprotective effect against alcoholic-mediated liver damage. Total...
Tanwarat Sanvoranart et al.
Biochemical and biophysical research communications, 447(4), 580-585 (2014-04-22)
Bortezomib (BZB) is a chemotherapeutic agent approved for treating multiple myeloma (MM) patients. In addition, there are several reports showing that bortezomib can induce murine mesenchymal stem cells (MSCs) to undergo osteogenic differentiation and increase bone formation in vivo. MSCs...
William C W Chen et al.
Stem cells (Dayton, Ohio), 33(2), 557-573 (2014-10-23)
Perivascular mesenchymal precursor cells (i.e., pericytes) reside in skeletal muscle where they contribute to myofiber regeneration; however, the existence of similar microvessel-associated regenerative precursor cells in cardiac muscle has not yet been documented. We tested whether microvascular pericytes within human...
Guiqi Qin et al.
Apoptosis : an international journal on programmed cell death, 20(8), 1072-1086 (2015-05-04)
This report is designed to dissect the detail molecular mechanism by which dihydroartemisinin (DHA), a derivative of artemisinin, induces apoptosis in human hepatocellular carcinoma (HCC) cells. DHA induced a loss of the mitochondrial transmemberane potential (ΔΨm), release of cytochrome c...
Niels Schlichting et al.
Molecular pharmaceutics, 11(7), 2092-2105 (2014-03-19)
In vitro tissue models are useful tools for the development of novel therapy strategies in cartilage repair and care. The limited availability of human primary tissue and high costs of animal models hamper preclinical tests of innovative substances and techniques....
Yan-Mei Lei et al.
Analytical chemistry, 87(15), 7787-7794 (2015-07-15)
In this paper, a novel electrochemiluminescence resonance energy transfer (ECL-RET) system from O2/S2O8(2-) to a kind of amino-terminated perylene derivative (PTC-NH2) was demonstrated for the first time, which was then applied to construct a ratiometric aptasensor for lead ion (Pb(2+))...
Fei Xu et al.
FEMS microbiology letters, 358(1), 98-105 (2014-07-24)
This study investigated inactivation of bacteria with ultraviolet light A irradiation in combination with vitamin K3 as a photosensitizer. Six bacteria including Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, and Escherichia coli suspended in vitamin K3 aqueous...
Wen-Jia Ai et al.
Stem cells and development, 24(11), 1320-1331 (2015-01-21)
A low-efficiency yield hinders the use of stem cells as a source of endothelial cells (ECs) for therapeutic vascularization, and the diversity of the transforming growth factor-β (TGF-β) superfamily has undermined understanding the effects of its potent vascularization-inducing. Herein, we...
Hongfei Ren et al.
Molecular medicine reports, 12(5), 6711-6717 (2015-09-24)
Bone remodeling is a vital physiological process of healthy bone tissue in humans. It is characterized by the formation of bone by osteoblasts and its resorption by osteoclasts, and the bone resorbed by osteoclasts is replaced through the differentiation and...
Katherine A Brown et al.
ACS nano, 8(10), 10790-10798 (2014-09-23)
Excited state electron transfer (ET) is a fundamental step for the catalytic conversion of solar energy into chemical energy. To understand the properties controlling ET between photoexcited nanoparticles and catalysts, the ET kinetics were measured for solution-phase complexes of CdTe...
Brett L Rosenberg et al.
Analytical chemistry, 87(17), 8651-8656 (2015-08-11)
Although actinides are the most informative elements with respect to the nature of a nuclear accident, plutonium analysis is complicated by the background created by fallout from atmospheric nuclear explosions. Therefore, we propose (239)Np, a short-lived actinide that emits several...
Gulsen Tel et al.
Pharmaceutical biology, 53(6), 824-830 (2015-02-28)
Recently, mushrooms are interesting natural products to be investigated due to exhibiting various bioactivities. This study determines the antioxidant and anticholinesterase activities of various extracts of five wild mushroom species. In addition, the total bioactive contents, namely, ascorbic acid, β-carotene...
Chao Fu et al.
Journal of cellular physiology, 230(9), 2184-2201 (2015-02-07)
Alpha-lipoic acid (ALA), a naturally occurring compound and dietary supplement, has been established as a potent antioxidant that is a strong scavenger of free radicals. Recently, accumulating evidences has indicated the relationship between oxidative stress and osteoporosis (OP). Some studies...
Masato Yuasa et al.
PloS one, 10(2), e0116462-e0116462 (2015-02-07)
We evaluated whether dexamethasone augments the osteogenic capability of bone marrow-derived stromal cells (BMSCs) and muscle tissue-derived stromal cells (MuSCs), both of which are thought to contribute to ectopic bone formation induced by bone morphogenetic protein-2 (BMP-2), and determined the...
R G Gomes et al.
Theriogenology, 84(5), 750-755 (2015-06-16)
The aim of this study was to evaluate the effects of different concentrations of ascorbic acid (25, 50, and 100 μg/mL) in supplemented minimum essential medium (MEM+) on the development of equine preantral follicles that were cultured in vitro for...
Colin A Lowery et al.
Bioorganic & medicinal chemistry letters, 15(9), 2395-2398 (2005-04-20)
Quorum sensing activity was investigated in the bacterium Vibrio harveyi using a series of both natural and nonnatural analogs of DPD, the penultimate precursor to autoinducer AI-2. The progression of molecules that were both synthesized and investigated includes enantiomeric variants...
Monica Dettin et al.
PloS one, 10(9), e0137505-e0137505 (2015-09-12)
The design of hybrid poly-ε-caprolactone (PCL)-self-assembling peptides (SAPs) matrices represents a simple method for the surface functionalization of synthetic scaffolds, which is essential for cell compatibility. This study investigates the influence of increasing concentrations (2.5%, 5%, 10% and 15% w/w...
Kosei Nakajima et al.
Neoplasia (New York, N.Y.), 16(11), 939-949 (2014-11-27)
Patients with bone cancer metastasis suffer from unbearable pain and bone fractures due to bone remodeling. This is caused by tumor cells that disturb the bone microenvironment. Here, we have investigated the role of tumor-secreted sugar-binding protein, i.e., galectin-3, on...
Bret H Clough et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(1), 83-94 (2014-08-19)
Although bone has remarkable regenerative capacity, about 10% of long bone fractures and 25% to 40% of vertebral fusion procedures fail to heal. In such instances, a scaffold is employed to bridge the lesion and accommodate osteoprogenitors. Although synthetic bone...
Xiaoping Liu et al.
The FEBS journal, 280(15), 3621-3631 (2013-05-29)
The endogenous vasodilator nitric oxide (NO) is metabolized in tissues in an oxygen-dependent manner. In skeletal and cardiac muscle, high concentrations of myoglobin (Mb) function as a potent NO scavenger. However, the Mb concentration is very low in vascular smooth...
Hyun Jung Park et al.
International journal of biological macromolecules, 78, 215-223 (2015-04-08)
Silk fibroin is a biomaterial being actively studied in the field of bone tissue engineering. In this study, we aimed to select the best strategy for bone reconstruction on scaffolds by changing various conditions. We compared the characteristics of each...
Vrunda Patel et al.
Pain practice : the official journal of World Institute of Pain, 12(6), 476-484 (2011-12-14)
Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have been associated with the damage to the gastrointestinal tract. One proposed mechanism of injury to the gastrointestinal mucosa by NSAIDs is oxygen radical-dependent microvascular injury. There is reasonable evidence to support the benefit...
Arnold Bolomsky et al.
Journal of hematology & oncology, 8, 10-10 (2015-04-19)
Insulin like growth factor binding protein 7 (IGFBP7) is a secreted protein binding insulin like growth factor 1 (IGF-1), insulin, vascular endothelial growth factor A (VEGFA), and activin A. It antagonizes bone morphogenetic proteins and is involved in the tumour...
Yoshitaka Kondo et al.
Journal of agricultural and food chemistry, 62(38), 9286-9295 (2014-09-03)
Potato chips (PC) contain abundant amounts of the free radical scavenger ascorbic acid (AA) due to the rapid dehydration of potato tubers (Solanum tuberosum) that occurs during frying. To evaluate the antioxidant activity of PC, this study examined reactive oxygen...
Sivaprakash Ramalingam et al.
Current gene therapy, 14(6), 461-472 (2014-09-24)
Generation and precise genetic correction of patient-derived hiPSCs have great potential in regenerative medicine. Such targeted genetic manipulations can now be achieved using gene-editing nucleases. Here, we report generation of cystic fibrosis (CF) and Gaucher's disease (GD) hiPSCs respectively from...
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