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A2218

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Valentina Trotta et al.
International journal of pharmaceutics, 491(1-2), 190-197 (2015-06-29)
The aim of the study was to prepare inhalable resveratrol by spray drying for the treatment of chronic obstructive pulmonary disease (COPD). Resveratrol, with a spherical morphology and particle diameter less than 5 μm, was successfully manufactured. Fine particle fraction...
Ilona Olędzka et al.
Journal of pharmaceutical and biomedical analysis, 102, 45-53 (2014-09-23)
The purpose of this work is the evaluation of the nutritional status of patients with cystic fibrosis (CF), based on the level of vitamin C in urine and vitamins A and E in serum, using the fast, selective and fully...
Holly R Harris et al.
European journal of cancer (Oxford, England : 1990), 50(7), 1223-1231 (2014-03-13)
The association between dietary vitamin C intake and breast cancer survival is inconsistent and few studies have specifically examined vitamin C supplement use among women with breast cancer. The purpose of this study was to summarise results from prospective studies...
Yanmei Dai et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 29(4), 364-367 (2013-05-07)
To investigate the effect of electrical stimulation on the differentiation of induced pluripotent stem cells (iPSCs) into cardiomyocytes in vitro. Classical hanging-drop method was used to induce iPSCs from mice to form embryoid bodies (EBs) and vitamin C was contained...
C Iborra-Bernad et al.
Journal of food science, 80(8), E1725-E1734 (2015-07-02)
In this paper, physico-chemical and structural properties of cut and cooked purple-flesh potato, green bean pods, and carrots have been studied. Three different cooking methods have been applied: traditional cooking (boiling water at 100 °C), cook-vide (at 80 and 90...
Claire E Schaar et al.
PLoS genetics, 11(2), e1004972-e1004972 (2015-02-12)
Reactive oxygen species (ROS) are highly reactive, oxygen-containing molecules that can cause molecular damage within the cell. While the accumulation of ROS-mediated damage is widely believed to be one of the main causes of aging, ROS also act in signaling...
J Reyes-Ocampo et al.
Neurotoxicology, 50, 81-91 (2015-08-10)
The kynurenines 3-hydroxyanthranilic acid (3-HANA) and its precursor 3-hydroxykynurenine (3-HK) are metabolites derived from tryptophan degradation. 3-HK, has been related to diverse neurodegenerative diseases including Huntington's, Alzheimer's and Parkinson's diseases that share mitochondrial metabolic dysregulation. Nevertheless, the direct effect of...
Murugesan Saravanakumar et al.
The British journal of nutrition, 114(9), 1385-1394 (2015-09-09)
In our previous studies, veratric acid (VA) shows beneficial effect on hypertension and its associated dyslipidaemia. In continuation, this study was designed to investigate the effect of VA, one of the major benzoic acid derivatives from vegetables and fruits, on...
E D N S Abeyrathne et al.
Poultry science, 94(9), 2280-2287 (2015-07-22)
Ovomucoid is well known as a "trypsin inhibitor" and is considered to be the main food allergen in egg. However, the negative functions of ovomucoid can be eliminated if the protein is cut into small peptides. The objectives of this...
Daniela Sieghart et al.
Journal of cellular and molecular medicine, 19(1), 187-197 (2014-10-15)
Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2 S) seems to affect cells involved in...
Lusine Danielyan et al.
Cell transplantation, 23 Suppl 1, S123-S139 (2014-10-11)
In view of the rapid preclinical development of cell-based therapies for neurodegenerative disorders, traumatic brain injury, and tumors, the safe and efficient delivery and targeting of therapeutic cells to the central nervous system is critical for maintaining therapeutic efficacy and...
SuJung Hu et al.
Food chemistry, 194, 1089-1094 (2015-10-17)
The antioxidant capacity and attributable bioactive compounds of puffed cacao beans were investigated. Roasting was carried out at 190°C for 15min and puffing was performed at 4-7kgf/cm(2). Cacao beans puffed at 4kgf/cm(2) showed the highest total polyphenols (23.16mgGAE/gsample) and total...
Jonathan Sagal et al.
Stem cells translational medicine, 3(8), 888-898 (2014-06-07)
Human pluripotent stem cells (PSCs) are a promising cell resource for various applications in regenerative medicine. Highly efficient approaches that differentiate human PSCs into functional lineage-specific neurons are critical for modeling neurological disorders and testing potential therapies. Proneural transcription factors...
Phil Jun Kang et al.
Biomaterials, 35(26), 7336-7345 (2014-06-03)
Somatic cells can be reprogrammed to generate induced pluripotent stem cells (iPSCs) by overexpression of four transcription factors, Oct4, Klf4, Sox2, and c-Myc. However, exogenous expression of pluripotency factors raised concerns for clinical applications. Here, we show that iPS-like cells...
Stephen Flowers et al.
Bone, 69, 47-54 (2014-09-04)
The retinoblastoma protein family is intimately involved in the regulation of tissue specific gene expression during mesenchymal stem cell differentiation. The role of the following proteins, pRB, p107 and p130, is particularly significant in differentiation to the osteoblast lineage, as...
S Cyboran et al.
Life sciences, 126, 1-9 (2015-02-24)
This study was undertaken to determine the biological activity of a green tea supplement with respect to cells and erythrocyte membranes and the molecular mechanism of that activity. The extract's activity was evaluated on the basis of its hemolytic, antioxidant...
Sawsan Aboul-Fotouh
Psychopharmacology, 232(6), 1095-1105 (2014-10-16)
Several studies have pointed to the nicotinic acetylcholine receptor (nAChR) antagonists, such as mecamylamine (MEC), as a potential therapeutic target for the treatment of depression. The present study evaluated the behavioral and neurochemical effects of chronic administration of MEC (1...
Tsung-Hsun Hsieh et al.
Cerebral cortex (New York, N.Y. : 1991), 25(7), 1806-1814 (2014-01-24)
Repetitive magnetic stimulation (rTMS), including theta burst stimulation (TBS), is capable of modulating motor cortical excitability through plasticity-like mechanisms and might have therapeutic potential for Parkinson's disease (PD). An animal model would be helpful for elucidating the mechanism of rTMS...
Harmeet S Sandhu et al.
Bioorganic & medicinal chemistry, 18(15), 5626-5633 (2010-07-14)
A series of arylidene analogues of Meldrum's acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The influence of various physico-chemical parameters such as dielectric constant (epsilon), donor number (DN), acceptor number (AN)...
L-ascorbic acid--clinical use, toxicity, properties, methods of determination and application in chemical analysis.
E Kleszczewska
Die Pharmazie, 55(9), 640-644 (2000-10-14)
Heinz-Dieter Müller et al.
Journal of endodontics, 41(11), 1852-1861 (2015-09-24)
Proangiogenic prolyl hydroxylase (PHD) inhibitors represent a novel approach to stimulate tissue regeneration. Diabetes mellitus involves the accumulation of advanced glycation end products (AGEs). Here we evaluated the impact of AGEs on the response of human pulp tissue to the...
Bruno Bosch Volpe et al.
Cytotherapy, 16(12), 1709-1719 (2014-10-13)
Surgical treatment for enterocutaneous fistulas (EF) frequently fails. Cell therapy may represent a new approach to treatment. Mesenchymal stromal cells (MSCs) have high proliferative and differentiation capacity. This study aimed to investigate whether MSCs could adhere to suture filament (SF)...
Dariela Almeda et al.
Biomaterials, 41, 37-44 (2014-12-20)
Liposomes may be engineered to target inflamed endothelium by mimicking ligand-receptor interactions between leukocytes and cytokine-activated endothelial cells (ECs). The upregulation and assembly of vascular cell adhesion molecule-1 (VCAM1) and E-selectin on the cell membrane upon exposure to cytokines have...
Sung Hugh Choi et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(2), 235-243 (2014-11-02)
Three type-1 repeat (3TSR) domain of thrombospondin-1 is known to have anti-angiogenic effects by targeting tumor-associated endothelial cells, but its effect on tumor cells is unknown. This study explored the potential of 3TSR to target glioblastoma (GBM) cells in vitro...
David Tagler et al.
Biotechnology and bioengineering, 111(7), 1417-1429 (2014-01-01)
The in vitro growth of ovarian follicles is an emerging technology for fertility preservation. Various strategies support the culture of secondary and multilayer follicles from various species including mice, non-human primate, and human; however, the culture of early stage (primary...
Lubica Horvathova et al.
Journal of neuroimmunology, 278, 255-261 (2014-12-04)
The sympathetic nervous system regulates many immune functions and modulates the anti-tumor immune defense response, too. Therefore, we studied the effect of 6-hydroxydopamine induced sympathectomy on selected hematological parameters and inflammatory markers in rats with Yoshida AH130 ascites hepatoma. We...
Guiqi Qin et al.
Apoptosis : an international journal on programmed cell death, 20(8), 1072-1086 (2015-05-04)
This report is designed to dissect the detail molecular mechanism by which dihydroartemisinin (DHA), a derivative of artemisinin, induces apoptosis in human hepatocellular carcinoma (HCC) cells. DHA induced a loss of the mitochondrial transmemberane potential (ΔΨm), release of cytochrome c...
Niels Schlichting et al.
Molecular pharmaceutics, 11(7), 2092-2105 (2014-03-19)
In vitro tissue models are useful tools for the development of novel therapy strategies in cartilage repair and care. The limited availability of human primary tissue and high costs of animal models hamper preclinical tests of innovative substances and techniques....
Yan-Mei Lei et al.
Analytical chemistry, 87(15), 7787-7794 (2015-07-15)
In this paper, a novel electrochemiluminescence resonance energy transfer (ECL-RET) system from O2/S2O8(2-) to a kind of amino-terminated perylene derivative (PTC-NH2) was demonstrated for the first time, which was then applied to construct a ratiometric aptasensor for lead ion (Pb(2+))...
Fei Xu et al.
FEMS microbiology letters, 358(1), 98-105 (2014-07-24)
This study investigated inactivation of bacteria with ultraviolet light A irradiation in combination with vitamin K3 as a photosensitizer. Six bacteria including Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, and Escherichia coli suspended in vitamin K3 aqueous...
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