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Daniel J Jackson et al.
Genome biology and evolution, 7(5), 1349-1362 (2015-04-29)
Brachiopods are a lineage of invertebrates well known for the breadth and depth of their fossil record. Although the quality of this fossil record attracts the attention of paleontologists, geochemists, and paleoclimatologists, modern day brachiopods are also of interest to...
Kim Nuytens et al.
PloS one, 9(10), e109598-e109598 (2014-10-22)
Two knockout mouse models for the autism candidate gene Neurobeachin (Nbea) have been generated independently. Although both models have similar phenotypes, one striking difference is the dwarf phenotype observed in the heterozygous configuration of the GH240B model that is generated...
Antonella Antignani et al.
Molecular cancer therapeutics, 13(6), 1655-1663 (2014-04-18)
Impaired apoptosis is often a key element in tumor development. Therefore, drugs mimicking prosurvival antagonists offer promise as cancer therapeutics. When ABT-737, a BH3-only mimetic, was added to KB3-1 human cervical adenocarcinoma cells, we noted an induction of an endoplasmic...
Julien Pujol et al.
Veterinary immunology and immunopathology, 168(1-2), 1-13 (2015-11-11)
Vaccination is the most cost-effective way to control infectious diseases in cattle. However, many infectious diseases leading to severe economical losses worldwide still remain for which a really effective and safe vaccine is not available. These diseases are most often...
Ping Liu et al.
Neurobiology of aging, 35(9), 1992-2003 (2014-04-22)
L-arginine is a semi-essential amino acid with a number of bioactive metabolites. Accumulating evidence suggests the implication of altered arginine metabolism in the pathogenesis of Alzheimer's disease (AD). The present study systematically compared the metabolic profile of L-arginine in the...
Rachel A Levin et al.
PloS one, 9(5), e97415-e97415 (2014-05-13)
We present an optimized triple modality reporter construct combining a far-red fluorescent protein (E2-Crimson), enhanced firefly luciferase enzyme (Luc2), and truncated wild type herpes simplex virus I thymidine kinase (wttk) that allows for sensitive, long-term tracking of tumor growth in...
Yunden Jinsmaa et al.
Neuroscience letters, 590, 134-137 (2015-02-01)
In Parkinson's disease (PD) alpha-synuclein oligomers are thought to be pathogenic, and 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate aldehyde intermediate in neuronal dopamine metabolism, potently oligomerizes alpha-synuclein. PD involves alpha-synuclein deposition in brainstem raphe nuclei; however, whether 5-hydroxyindoleacetaldehyde (5-HIAL), the aldehyde of...
Zhihua Liu et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(5), 698-702 (2015-02-25)
CYP2A13 is a human cytochrome P450 (P450) enzyme important in the bioactivation of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). CYP2A13 expression levels vary dramatically among lung biopsy samples from patients, presumably owing in part to a suppression of CYP2A13 expression...
Jun Okabe et al.
ChemMedChem, 9(8), 1755-1762 (2014-05-23)
The enzymatic activities of protein methyltransferases serve to write covalent modifications on histone and non-histone proteins in the control of gene transcription. Here, we describe gene expression changes in human endothelial cells caused by treatment with methyltransferase inhibitors 7,7'-carbonylbis (azanediyl)...
Nicole A Kruh-Garcia et al.
Journal of proteomics, 97, 141-150 (2013-07-31)
Mycobacterium tuberculosis secretes several hundred proteins; many of which elicit immune responses. As a result, many of these proteins have been explored for their potential as diagnostic and vaccine candidates. Of these, the Antigen 85 complex proteins, represented by Antigen85...
Philippe R Montgrain et al.
SpringerPlus, 4, 268-268 (2015-06-20)
Parathyroid hormone-related protein (PTHrP) inhibits proliferation of several lung cancer cell lines, but the signaling mechanism has not been established. This study tested the hypotheses that growth inhibition is mediated through the PTHrP receptor, PTH1R, and that the process is...
Heather J Galipeau et al.
The American journal of pathology, 185(11), 2969-2982 (2015-10-13)
Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. The recent increase in CD incidence suggests that additional environmental factors, such as intestinal microbiota alterations, are involved in its pathogenesis. However, there is no direct...
Maria B Lebron et al.
Cancer biology & therapy, 15(9), 1208-1218 (2014-06-13)
Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of...
David W Greening et al.
Oncotarget, 6(35), 38166-38180 (2015-10-31)
Angiogenesis and epidermal growth factor receptor (EGFR) inhibition has been shown to have anti-tumour efficacy, and enhance the therapeutic effects of cytotoxic chemotherapy in metastatic colorectal cancer. The interplay of signalling alterations and changes in metabolism and hypoxia in tumours...
Patricia M Gaffney et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(3), 911-919 (2014-11-26)
Pathologic amyloid accumulates in the CNS or in peripheral organs, yet the mechanism underlying the targeting of systemic amyloid deposits is unclear. Serum amyloid A (SAA) 1 and 2 are produced predominantly by the liver and form amyloid most commonly...
Diana F Lázaro et al.
PLoS genetics, 10(11), e1004741-e1004741 (2014-11-14)
Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic forms of PD, suggesting...
Rym Chioukh et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2041-2048 (2014-09-23)
The coadministration of methotrexate (MTX) and proton pump inhibitors (PPIs) can result in a pharmacokinetic interaction that delays MTX elimination and subsequently increases the MTX blood concentrations. Human organic anion transporters (hOATs) are responsible for the renal tubular secretion of...
You-Min Lin et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(5), G434-G441 (2014-12-30)
Abdominal pain and distention are major complaints in irritable bowel syndrome. Abdominal distention is mainly attributed to intraluminal retention of gas or solid contents, which may cause mechanical stress to the gut wall. Visceral hypersensitivity (VHS) may account for abdominal...
Erica C Nakajima et al.
PloS one, 9(8), e102452-e102452 (2014-08-16)
Intratumoral metabolic heterogeneity may increase the likelihood of treatment failure due to the presence of a subset of resistant tumor cells. Using a head and neck squamous cell carcinoma (HNSCC) xenograft model and a real-time fluorescence imaging approach, we tested...
Elisabeth Zapatero-Solana et al.
Orphanet journal of rare diseases, 9, 211-211 (2014-12-22)
Kindler Syndrome (KS) is an autosomal recessive skin disorder characterized by skin blistering, photosensitivity, premature aging, and propensity to skin cancer. In spite of the knowledge underlying cause of this disease involving mutations of FERMT1 (fermitin family member 1), and...
Marek M Nagiec et al.
PloS one, 10(3), e0120295-e0120295 (2015-03-27)
Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and is associated with lower plasma levels of...
Chih-Lun Cheng et al.
Journal of biomedical science, 22, 103-103 (2015-11-18)
Highly desaturated n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are synthesized by desaturases and elongase. They exert hepatoprotective effects to prevent alcoholic fatty liver syndrome or cholestatic liver injury. However, it is unclear...
Nina Kaukua et al.
Stem cell research & therapy, 6, 59-59 (2015-05-01)
Deciduous and permanent human teeth represent an excellent model system to study aging of stromal populations. Aging is tightly connected to self-renewal and proliferation and thus, mapping potential molecular differences in these characteristics between populations constitutes an important task. Using...
Kevin C Gough et al.
Respiratory research, 16, 86-86 (2015-07-16)
Human lung mast cells (HLMCs) infiltrate the airway epithelium and airway smooth muscle (ASM) in asthmatic airways. The mechanism of HLMC adhesion to both cell types is only partly defined, and adhesion is not inhibited by function-blocking anti-Kit and anti-stem...
Elizabeth S Chan et al.
Scientific reports, 5, 13842-13842 (2015-09-09)
It is unclear how human apolipoprotein E4 (ApoE4) increases the risk for Alzheimer's disease (AD). Although Aβ levels can lead to insulin signaling impairment, these experiments were done in the absence of human ApoE. To examine ApoE role, we crossed...
Synnøve Magnussen et al.
PloS one, 9(8), e105929-e105929 (2014-08-27)
The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the...
Jessica L Andrews et al.
Progress in neuro-psychopharmacology & biological psychiatry, 63, 91-97 (2015-06-15)
Postnatal administration of phencyclidine (PCP) in rodents causes major disturbances to neurological processes resulting in severe modifications to normal behavioral traits into adulthood. It is routinely used to model psychiatric disorders such as schizophrenia, producing many of the dysfunctional processes...
Jelena Lazovic et al.
Neuro-oncology, 17(1), 53-62 (2014-07-31)
Nitroxoline is an FDA-approved antibiotic with potential antitumor activity. Here we evaluated whether nitroxoline has antiproliferative properties on glioma cell growth in vitro and in vivo using glioma cell lines and a genetically engineered PTEN/KRAS mouse glioma model. The effect...
Anita Dreyer et al.
PLoS neglected tropical diseases, 9(2), e0003477-e0003477 (2015-02-11)
Buruli ulcer (BU) caused by Mycobacterium ulcerans is a devastating skin disease, occurring mainly in remote West African communities with poor access to health care. Early case detection and subsequent antibiotic treatment are essential to counteract the progression of the...
Anette Brass et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(3), 578-590 (2014-12-11)
Current therapies for the hepatitis B virus (HBV), a major cause of severe liver disease, suppress viral replication but replication rebounds if therapy is withdrawn. It is widely accepted that immune activation is needed to control replication off-therapy. To specifically...
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