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Péter Lőrincz et al.
eLife, 8 (2019-06-14)
Two related multisubunit tethering complexes promote endolysosomal trafficking in all eukaryotes: Rab5-binding CORVET that was suggested to transform into Rab7-binding HOPS. We have previously identified miniCORVET, containing Drosophila Vps8 and three shared core proteins, which are required for endosome maturation
Sonia Feu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6907-6919 (2020-04-09)
DNA replication is essential for cell proliferation and is one of the cell cycle stages where DNA is more vulnerable. Replication stress is a prominent property of tumor cells and an emerging target for cancer therapy. Although it is not
Markus Alexander Doll et al.
Genetics, 213(1), 173-194 (2019-07-13)
MicroRNAs (miRNAs) associate with argonaute (AGO) proteins to post-transcriptionally modulate the expression of genes involved in various cellular processes. Herein, we show that loss of the Caenorhabditis elegans AGO gene alg-2 results in rapid and significantly increased germ cell apoptosis
Dingwen Hu et al.
Virulence, 12(1), 1795-1807 (2021-07-21)
Zika virus (ZIKV) infection can cause severe neurological disorders, including Guillain-Barre syndrome and meningoencephalitis in adults and microcephaly in fetuses. Here, we reveal that laminin receptor 1 (LAMR1) is a novel host resistance factor against ZIKV infection. Mechanistically, we found
Bianca Schaefer et al.
PloS one, 12(11), e0188344-e0188344 (2017-11-21)
It has recently been shown that signal peptide peptidase (SPP) can catalyze the intramembrane cleavage of heme oxygenase-1 (HO-1) that leads to translocation of HO-1 into the cytosol and nucleus. While there is consensus that translocated HO-1 promotes tumor progression
Forn-Chia Lin et al.
Journal of biomedical science, 21, 75-75 (2014-08-28)
Pin1 promotes oncogenesis by regulating multiple oncogenic signaling. In this study, we investigated the involvement of Pin1 in tumor progression and in the prognosis of human esophageal squamous cell carcinoma (ESCC). We observed that proliferation, clonogenicity and tumorigenesis of CE81T
Qing Wang et al.
Journal of neuroinflammation, 15(1), 184-184 (2018-06-17)
Amplified inflammation is important for the progression of Parkinson's disease (PD). However, how this enhanced inflammation is regulated remains largely unknown. Deletion of DICER leads to progressive dopamine neuronal loss and induces gliosis. We hypothesized that the homeostasis of microglial
Ilenia Bernascone et al.
Nature communications, 10(1), 2481-2481 (2019-06-07)
Mammary stroma is essential for epithelial morphogenesis and development. Indeed, postnatal mammary gland (MG) development is controlled locally by the repetitive and bi-directional cross-talk between the epithelial and the stromal compartment. However, the signalling pathways involved in stromal-epithelial communication are
Daniela Justa-Schuch et al.
Cellular and molecular life sciences : CMLS, 71(18), 3611-3626 (2014-02-25)
The intracellular prolyl peptidase DPP9 is implied to be involved in various cellular pathways including amino acid recycling, antigen maturation, cellular homeostasis, and viability. Interestingly, the major RNA transcript of DPP9 contains two possible translation initiation sites, which could potentially
C J J Boogerd et al.
Cellular and molecular life sciences : CMLS, 68(23), 3949-3961 (2011-05-04)
Tbx3, a T-box transcription factor, regulates key steps in development of the heart and other organ systems. Here, we identify Sox4 as an interacting partner of Tbx3. Pull-down and nuclear retention assays verify this interaction and in situ hybridization reveals
Jennetta W Hammond et al.
Traffic (Copenhagen, Denmark), 9(5), 725-741 (2008-02-13)
Kinesin motors drive the intracellular transport of multiple cargoes along microtubule tracks; yet, how kinesins discriminate among their many potential cargoes is unknown. We tested whether Kinesin-1 cargoes compete, co-operate or are transported independently of each other. We focused on
Cui Zhang et al.
Developmental cell, 55(5), 603-616 (2020-11-25)
Axillary meristems (AMs) give rise to lateral shoots and are critical to plant architecture. Understanding how developmental cues and environmental signals impact AM development will enable the improvement of plant architecture in agriculture. Here, we show that ARGONAUTE10 (AGO10), which sequesters
Amina F Zebboudj et al.
The Journal of biological chemistry, 277(6), 4388-4394 (2001-12-14)
Matrix GLA protein (MGP) has been identified as a calcification inhibitor in cartilage and vasculature. Part of this effect may be attributed to its influence on osteoinductive activity of bone morphogenetic protein-2 (BMP-2). To detect binding between MGP and BMP-2
Rexhep Uka et al.
Oncogene, 39(20), 4132-4154 (2020-04-03)
Despite advances in the systemic treatment of patients with metastatic melanoma using immune checkpoint and tyrosine kinase inhibitors (TKI), the majority of stage IV melanoma patients eventually succumb to the disease. We have previously identified the transcription factor Sox10 as
Bangbao Tao et al.
Molecular oncology, 13(5), 1018-1032 (2019-01-13)
Recent studies have revealed that neurons can promote glioma growth through activity-dependent secretion of neurotrophins, especially neuroligin-3. It has therefore been suggested that blocking neuron-derived neurotrophins may serve as a therapeutic intervention for gliomas. Carbonic anhydrase-related proteins 11 and 10
Riya Sarkar et al.
The Journal of general virology, 102(1) (2020-10-24)
Microtubule-associated protein 1 light chain 3 (MAP1LC3) is a protein with a well-defined function in autophagy, but still incompletely understood roles in several other autophagy-independent processess. Studies have shown MAP1LC3 is a host-dependency factor for the replication of several viruses.
Man Xiong et al.
Cell stem cell, 28(1), 112-126 (2020-09-24)
Although cell transplantation can rescue motor defects in Parkinson's disease (PD) models, whether and how grafts functionally repair damaged neural circuitry in the adult brain is not known. We transplanted hESC-derived midbrain dopamine (mDA) or cortical glutamate neurons into the
Xiaofeng Liu et al.
EMBO reports, 17(3), 349-366 (2016-02-18)
As a genome guardian, p53 maintains genome stability by arresting cells for damage repair or inducing cell apoptosis to eliminate the damaged cells in stress response. Several nucleolar proteins stabilize p53 by interfering Mdm2-p53 interaction upon cellular stress, while other
Linyong Du et al.
The Journal of experimental medicine, 217(11) (2020-08-30)
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of the β-catenin/TCF/LEF complex to the CD274 gene promoter region to induce PD-L1 expression, in which AKT
Janet C Reid et al.
American journal of cancer research, 7(11), 2257-2274 (2017-12-09)
We provide evidence of a pericellular network of proteases that are elevated and co-expressed in prostate cancer. The network involves the membrane bound serine proteases hepsin and TMPRSS2, the secreted kallikrein-related peptidases KLK4 and KLK14, and the secreted matrix metalloproteinases
Huan Liu et al.
Experimental neurology, 241, 125-137 (2012-12-25)
The olfactory system continuously incorporates new neurons into functional circuits throughout life. Axons from olfactory sensory neurons (OSNs) in the nasal cavity synapse on mitral, tufted and periglomerular (PG) cells in the main olfactory bulb, and low levels of turnover
Chang-Jiang Yu et al.
Hypertension (Dallas, Tex. : 1979), 69(4), 615-624 (2017-02-23)
Pathological cardiac hypertrophy is a key risk factor for heart failure. We found that the protein expression levels of the ZNF307 (zinc finger protein 307) were significantly increased in heart samples from both human patients with dilated cardiomyopathy and mice
Canhe Chen et al.
iScience, 11, 114-133 (2019-01-06)
Timely centrosome separation is critical for accurate chromosome separation. It is initiated by Nek2A at the onset of mitosis, but the mechanism for the strict requirement of phosphorylated Nek2A for its own activation remains unclear. In this study, we have
Richard S Marshall et al.
Journal of cell science, 133(21) (2020-10-10)
The core protease (CP) subcomplex of the 26S proteasome houses the proteolytic active sites and assumes a barrel shape comprised of four co-axially stacked heptameric rings formed by structurally related α- and β-subunits. CP biogenesis typically begins with the assembly
Elizabeth G Pitts et al.
Scientific reports, 8(1), 4495-4495 (2018-03-16)
Specific corticostriatal structures and circuits are important for flexibly shifting between goal-oriented versus habitual behaviors. For example, the orbitofrontal cortex and dorsomedial striatum are critical for goal-directed action, while the dorsolateral striatum supports habits. To determine the role of neurotrophin
Julie Candiracci et al.
Science advances, 5(6), eaav0184-eaav0184 (2019-06-22)
Nutrient availability has a profound impact on cell fate. Upon nitrogen starvation, wild-type fission yeast cells uncouple cell growth from cell division to generate small, round-shaped cells that are competent for sexual differentiation. The TORC1 (TOR complex 1) and TORC2
Huan-Tian Zhang et al.
Cell death & disease, 12(1), 21-21 (2021-01-09)
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, which is characterized by dysfunctional autophagy and poor differentiation. Our recent studies have suggested that the tripartite motif containing-21 (TRIM21) plays a crucial role in regulating
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