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Glenn S Murphy et al.
Anesthesiology, 122(5), 1112-1122 (2015-04-04)
The intensity of pain after cardiac surgery is often underestimated, and inadequate pain control may be associated with poorer quality of recovery. The aim of this investigation was to examine the effect of intraoperative methadone on postoperative analgesic requirements, pain...
Dharmesh R Chejara et al.
Carbohydrate polymers, 135, 324-333 (2015-10-11)
In this article a novel bio-injectable algin-aminocaproic acid (Alg-ACA) tri-stimuli responsive thixogel system is reported. The designed soft thixotrophic hydrogel (thixogel) was characterized using various analytical techniques such as FT-IR, NMR, SEM, AFM and DSC. The soft thixogel system was...
Sylvie Bannwarth et al.
Brain : a journal of neurology, 137(Pt 8), 2329-2345 (2014-06-18)
Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are extremely rare. We report a large family with a late-onset phenotype including motor neuron disease, cognitive decline resembling frontotemporal...
María de los Angeles Serrano et al.
Zygote (Cambridge, England), 23(1), 99-110 (2013-07-31)
The objective of this study was to elucidate the signalling pathways initiated by cAMP once inside the Xenopus laevis oocyte, where it triggers and maintains vitellogenin endocytic uptake. Our results showed the presence of Xepac transcripts at all stages of...
Duygu Yilmaz et al.
European biophysics journal : EBJ, 44(7), 557-565 (2015-08-20)
A number of techniques developed to investigate protein structure and function depend on chemically modifying and/or labeling of proteins. However, in the case of homooligomeric proteins, the presence of multiple identical subunits obstructs the introduction of residue-specific labels to only...
Sebastian F Barreto-Ortiz et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3302-3314 (2015-04-23)
Despite current advances in engineering blood vessels over 1 mm in diameter and the existing wealth of knowledge regarding capillary bed formation, studies for the development of microvasculature, the connecting bridge between them, have been extremely limited so far. Here...
Yi Min et al.
Journal of pharmaceutical and biomedical analysis, 114, 247-253 (2015-06-16)
Superficially porous particles (SPPs) demonstrate superior efficiency than totally porous particles in chiral separations. In order to obtain high efficiency and fast separation, sub-2 μm SPPs with high surface area are synthesized, and with teicoplanin bonded, such materials are successfully...
K Kluckova et al.
Cell death & disease, 6, e1749-e1749 (2015-05-08)
Respiratory complex II (CII, succinate dehydrogenase, SDH) inhibition can induce cell death, but the mechanistic details need clarification. To elucidate the role of reactive oxygen species (ROS) formation upon the ubiquinone-binding (Qp) site blockade, we substituted CII subunit C (SDHC)...
Rameshwar R Rao et al.
Tissue engineering. Part A, 21(3-4), 530-540 (2014-09-18)
Minimally invasive, injectable bone tissue engineering therapies offer the potential to facilitate orthopedic repair procedures, including in indications where enhanced bone regeneration is needed for complete healing. In this study, we developed a dual-phase tissue construct consisting of osteogenic (Osteo)...
Kun Shao et al.
Advanced healthcare materials, 4(2), 291-300 (2014-08-16)
Due to complication factors such as blood-brain barrier (BBB), integrating high efficiency of brain target ability with specific cargo releasing into one nanocarrier seems more important. A brain targeting nanoscale system is developed using dehydroascorbic acid (DHA) as targeting moiety....
Measuring and Modeling Activity Coefficients in Aqueous Amino-Acid Solutions
Held, C, Cameretti, L, and Sadowski, G.
Ind. and Eng. Chem., 50, 131-141 (2011)
Raj Shah et al.
Cancer research, 79(8), 1799-1809 (2019-04-17)
Aberrant glutamatergic signaling has been implicated in altered metabolic activity in many cancer types, including malignant melanoma. Previously, we have illustrated the role of metabotropic glutamate receptor 1 (GRM1) in neoplastic transformation of melanocytes in vitro and spontaneous metastatic melanoma...
Julia V Monjarás Feria et al.
mBio, 6(5), e01459-e01415 (2015-10-16)
Type III secretion systems (T3SSs) are multiprotein machines employed by many Gram-negative bacteria to inject bacterial effector proteins into eukaryotic host cells to promote bacterial survival and colonization. The core unit of T3SSs is the needle complex, a supramolecular structure...
Nabaneeta Mukhopadhyay et al.
Physical chemistry chemical physics : PCCP, 17(6), 4293-4310 (2015-01-13)
Blends of polypropylene (PP) and polyamide 6 (PA6) with multiwalled carbon nanotubes (MWNTs) were prepared using different processing strategies in a twin-screw micro-compounder. The effect of MWNTs on the crystallization behaviour of the PP phase and the PA6 phase of...
Maria Kawalec et al.
PloS one, 10(7), e0134162-e0134162 (2015-08-01)
Mitofusin 2 (Mfn2), mitochondrial outer membrane protein which is involved in rearrangement of these organelles, was first described in pathology of hypertension and diabetes, and more recently much attention is paid to its functions in Charcot-Marie-Tooth type 2A neuropathy (CMT2A)....