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Shruthi Sriramkumar et al.
Molecular cancer research : MCR, 18(11), 1699-1710 (2020-08-18)
Platinum resistance is a common occurrence in high-grade serous ovarian cancer and a major cause of ovarian cancer deaths. Platinum agents form DNA cross-links, which activate nucleotide excision repair (NER), Fanconi anemia, and homologous recombination repair (HRR) pathways. Chromatin modifications...
Luisa Mori et al.
Journal of virology (2020-11-27)
HIV transcription requires assembly of cellular transcription factors at the HIV-1promoter. The TFIIH general transcription factor facilitates transcription initiation by opening the DNA strands around the transcription start site and phosphorylating the C-terminal domain for RNA polymerase II (RNAPII) for...
Jae-Seon Lee et al.
Theranostics, 11(7), 3472-3488 (2021-02-05)
Rationale: The activity of aldehyde dehydrogenase 7A1 (ALDH7A1), an enzyme that catalyzes the lipid peroxidation of fatty aldehydes was found to be upregulated in pancreatic ductal adenocarcinoma (PDAC). ALDH7A1 knockdown significantly reduced tumor formation in PDAC. We raised a question...
Umar Saeed et al.
Journal of virology, 93(6) (2018-12-21)
The parvulin 14 (Par14) and parvulin 17 (Par17) proteins, which are both encoded by the PIN4 gene, play roles in protein folding, chromatin remodeling, DNA binding, ribosome biogenesis, and cell cycle progression. However, the effects of Par14 and Par17 on...
Yao Jiang et al.
Nature communications, 10(1), 1515-1515 (2019-04-05)
Akt plays indispensable roles in cell proliferation, survival and metabolism. Mechanisms underlying posttranslational modification-mediated Akt activation have been extensively studied yet the Akt interactome is less understood. Here, we report that SAV1, a Hippo signaling component, inhibits Akt, a function...
Sara L Sinicropi-Yao et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 14(2), 223-236 (2018-11-09)
Notch receptor family dysregulation can be tumor promoting or suppressing depending on cellular context. Our studies shed light on the mechanistic differences that are responsible for NOTCH1's opposing roles in lung adenocarcinoma and lung squamous cell carcinoma. We integrated transcriptional...
Mei Zhou et al.
Breast cancer research and treatment, 185(2), 343-357 (2020-10-16)
Cancer stem cells (CSCs) are highly tumorigenic, spared by chemotherapy, sustain tumor growth, and are implicated in tumor recurrence after conventional therapies in triple negative breast cancer (TNBC). Lysine-specific histone demethylase 1A (KDM1A) is highly expressed in several human malignancies...
Yong Pu et al.
Archives of toxicology, 93(6), 1665-1677 (2019-04-23)
Tributyltin (TBT), an organotin chemical used as a catalyst and biocide, can stimulate cholesterol efflux in non-steroidogenic cells. Since cholesterol is the first limiting step for sex hormone production, we hypothesized that TBT disrupts intracellular cholesterol transport and impairs steroidogenesis...
A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells
Di P, et al.
BMC Cancer, 14(1), 292-292 (2014)
Bhavani S Sahu et al.
Cell reports, 28(10), 2567-2580 (2019-09-05)
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Even small changes in sequence can alter receptor activation, affecting therapeutic efficacy. We conducted a structure-function relationship study on the neuropeptide TLQP-21, a promising target for obesity...
Hanna Witwicka et al.
Molecular and cellular biology, 39(19) (2019-07-17)
Calcineurin (Cn) is a calcium-activated serine/threonine protein phosphatase that is broadly implicated in diverse cellular processes, including the regulation of gene expression. During skeletal muscle differentiation, Cn activates the nuclear factor of activated T-cell (NFAT) transcription factor but also promotes...
Changliang Chen et al.
Oncogene, 39(14), 2921-2933 (2020-02-08)
High-grade serous carcinoma, accounts for up to 70% of all ovarian cases. Furin, a proprotein convertase, is highly expressed in high-grade serous carcinoma of ovarian cancer patients, and its expression is even higher in tumor omentum than in normal omentum...
Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
Sun, et al.
The Embo Journal, 39, e103420-e103420 (2021)
Sarah C Starossom et al.
Nature communications, 10(1), 217-217 (2019-01-16)
In demyelinating diseases including multiple sclerosis (MS), neural stem cells (NSCs) can replace damaged oligodendrocytes if the local microenvironment supports the required differentiation process. Although chitinase-like proteins (CLPs) form part of this microenvironment, their function in this differentiation process is...
Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells
Humbert M, et al.
Leukemia Research, 36(12), 1552-1556 (2012)
Ermira Pazolli et al.
Cancer research, 69(3), 1230-1239 (2009-01-22)
Alterations in the tissue microenvironment collaborate with cell autonomous genetic changes to contribute to neoplastic progression. The importance of the microenvironment in neoplastic progression is underscored by studies showing that fibroblasts isolated from a tumor stimulate the growth of preneoplastic...
Sun-Ji Park et al.
Free radical biology & medicine, 108, 44-55 (2017-03-23)
Luteal regression is a natural and necessary event to regulate the reproductive process in all mammals. Prostaglandin F2α (PGF2α) is the main factor that causes functional and structural regression of the corpus luteum (CL). It is well known that PGF2α-mediated...
Florian Haun et al.
Nature communications, 9(1), 3524-3524 (2018-09-01)
Anoikis is a form of apoptosis induced by cell detachment. Integrin inactivation plays a major role in the process but the exact signalling pathway is ill-defined. Here we identify an anoikis pathway using gliotoxin (GT), a virulence factor of the...
Min Soo Kim et al.
Cancers, 12(8) (2020-08-01)
We have previously observed that tropomyosin receptor kinase B (TrkB) induces breast cancer metastasis by activating both the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) and phosphatidylinositol-3-Kinase (PI3K)/AKT signaling pathways and inhibiting runt-related transcription factor 3 (RUNX3)...
Hideo Tomihara et al.
Cancer research, 81(2), 332-343 (2020-11-08)
Cellular dedifferentiation is a key mechanism driving cancer progression. Acquisition of mesenchymal features has been associated with drug resistance, poor prognosis, and disease relapse in many tumor types. Therefore, successful targeting of tumors harboring these characteristics is a priority in...
Andrew R Chin et al.
Journal of mammary gland biology and neoplasia, 23(3), 165-176 (2018-07-04)
Extracellular vesicles (EVs) are secreted by many cell types and are increasingly investigated for their role in human diseases including cancer. Here we focus on the secretion and potential physiological function of non-pathological EVs secreted by polarized normal mammary epithelial...
Esha Madan et al.
Nucleic acids research, 47(19), 10212-10234 (2019-09-21)
Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer. At the molecular level, hypoxia manifests its effects via activation of HIF-dependent transcription. On the other hand, an...
Somasish Ghosh Dastidar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(45), 8734-8745 (2020-10-14)
Decline of protein quality control in neurons contributes to age-related neurodegenerative disorders caused by misfolded proteins. 4E-BP1 is a key node in the regulation of protein synthesis, as activated 4E-BP1 represses global protein translation. Overexpression of 4E-BP1 mediates the benefits...
Praveen Kumar Jaiswal et al.
Scientific reports, 8(1), 7459-7459 (2018-05-12)
eIF4G1, a critical component of the eIF4F complex, is required for cap-dependent mRNA translation, a process necessary for tumor growth and survival. However, the role of eIF4G1 has not been evaluated in Prostate Cancer (PCa). We observed an increased eIF4G1...
Sushil Kumar et al.
Oncogene, 38(12), 2092-2107 (2018-11-18)
Aberrant Notch signaling is implicated in several cancers, including breast cancer. However, the mechanistic details of the specific receptors and function of ligand-mediated Notch signaling that promote breast cancer remains elusive. In our studies we show that DLL1, a Notch...
Xuechong Hong et al.
Scientific reports, 7(1), 5590-5590 (2017-07-19)
Endothelial dysfunction is widely implicated in cardiovascular pathological changes and development of vascular disease. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great interest to explore alternative...
Jesús García-Cano et al.
Molecular oncology, 14(1), 69-86 (2019-10-31)
The p53 tumor suppressor protein is a transcription factor that plays a prominent role in protecting cells from malignant transformation. Protein levels of p53 and its transcriptional activity are tightly regulated by the ubiquitin E3 ligase MDM2, the gene expression...
Kwame Osei-Sarfo et al.
PloS one, 14(4), e0215234-e0215234 (2019-04-13)
To gain a greater understanding of oral squamous cell carcinoma (OSCC) we investigated the actions of all-trans-retinoic acid (RA; a retinoid), bexarotene (a pan-RXR agonist), and forkhead box (FOX) transcription factors in human OSCC-derived cell lines. RA and bexarotene have...
D M Fernández-Aroca et al.
Cancer letters, 451, 23-33 (2019-03-16)
Targeting cell cycle has become one of the major challenges in cancer therapy, being Palbociclib, a CDK4/6 inhibitor, an excellent example. Recently, it has been reported that Palbociclib could be a novel radiosensitizer agent. In an attempt to clarify the...
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