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Marina Figliuzzi et al.
Archives of toxicology, 94(9), 2965-2979 (2020-06-25)
Road traffic is one of the main sources of particulate emissions into the environment and has an increasing, negative impact on the release of potentially dangerous materials. Vehicle brakes release a significant amount of wear particles, and knowledge regarding their
Na Xu et al.
International journal of molecular sciences, 19(12) (2018-12-16)
Morchella conica Pers. (M. conica) has been used both as a medical and edible mushroom and possesses antimicrobial properties and antioxidant activities. However, the antioxidant properties of polysaccharides purified from M. conica have not been studied. The aim of this
Zhen Dong et al.
British journal of cancer, 116(12), 1572-1584 (2017-05-12)
Backgroud:Glioblastoma is a kind of highly malignant and aggressive tumours in the central nervous system. Previously, we found that neurotensin (NTS) and its high-affinity receptor 1 (NTSR1) had essential roles in cell proliferation and invasiveness of glioblastoma. Unexpectedly, cell death
Hye Young Kim et al.
Cancer letters, 355(1), 61-69 (2014-09-15)
Previous studies have revealed that HBx expression has anti-apoptotic effects, resulting in increased drug resistance in HCC cells. Thus, we examined if sorafenib efficiently induces apoptosis in HBx-overexpressing HCC cells. Noticeably, sorafenib efficiently induced apoptosis, even in HBx-expressing HepG2 cells
Zengenni Liang et al.
International journal of molecular sciences, 20(3) (2019-01-27)
Ganoderma lucidum polysaccharide (GLP) extracted from Ganoderma lucidum (Leyss. ex Fr.) Karst, a traditional Chinese medicine, is a biologically active substance reported to possess anti-oxidative, anti-apoptotic, and neurological protection. However, it is unknown whether GLP have any protective effect against
Md Mohibbullah et al.
Journal of medicinal food, 18(9), 960-971 (2015-06-25)
Age-related neurological disorders are of growing concern among the elderly, and natural products with neuroprotective properties have been attracting increasing attention as candidates for the prevention or treatment of neurological disorders induced by oxidative stress. In an effort to explore
Jun Ho Yang et al.
Cells, 8(5) (2019-05-17)
Lipid emulsion (LE) therapy has been used to reduce overdose of bupivacaine (BPV)-induced cardiotoxicity. The TWIK-related potassium channel-1 (TREK-1) is inhibited by BPV and activated by polyunsaturated fatty acids, which are the main component in LE. These pharmacological properties inspired
Luciana Costa et al.
PloS one, 9(10), e109672-e109672 (2014-10-24)
Previous results demonstrate that the hybrid synthetic pterocarpanquinone LQB-118 presents antileishmanial activity against Leishmania amazonensis in a mouse model. The aim of the present study was to use a hamster model to investigate whether LQB-118 presents antileishmanial activity against Leishmania
Shou-Ping Shih et al.
Marine drugs, 13(5), 3132-3153 (2015-05-27)
A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferation of Molt 4, K562, MDA-MB-231 and DLD-1 cancer cell lines, with IC50 of 0.48, 0.18, 8.0 and 6.76 μg/mL, respectively. It exhibited the most potent activity against
Yafei Zheng et al.
Neurochemical research, 44(7), 1549-1566 (2019-05-17)
This study aimed to investigate the potential effects of gold nanoparticles (Au-NPs) on rat cortical neurons exposed to oxygen-glucose deprivation/reperfusion (OGD/R) and to elucidate the corresponding mechanisms. Primary rat cortical neurons were exposed to OGD/R, which is commonly used in
Liu Han et al.
Experimental and therapeutic medicine, 19(3), 1864-1870 (2020-02-28)
Propofol is a widely used intravenous anesthetic shown to exert a cardioprotective role against oxidative stress and ischemia/reperfusion injury in rat cardiac H9c2 cells. However, the regulatory mechanisms and functions of propofol in human cardiomyocytes remain unknown. The present study
Bin Lai et al.
Oncology letters, 18(1), 442-448 (2019-07-11)
Although gastric cancer therapy has been improved, more efficient treatment strategies still need to be developed. In the present study, a docetaxel (DOC)-loaded lipid microbubble (DLLD) was prepared and the effect of DLLD combined with ultrasound-triggered microbubble destruction (UTMD) on
Yayuan Lu et al.
Aging, 12(1), 844-865 (2020-01-14)
Postoperative delirium (POD) is a common complication following surgery and anesthesia (Surgery/Anesthesia). Mitochondrial dysfunction, which is demonstrated by energy deficits and excessively activated oxidative stress, has been reported to contribute to POD. The dynamic balance between mitochondrial fusion and fission
Elinor Hortle et al.
Scientific reports, 9(1), 6356-6356 (2019-04-25)
Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines.
Tommaso Di Palma et al.
Zygote (Cambridge, England), 28(4), 300-307 (2020-04-15)
Information on donkey sperm bioenergetics, kinetics and oxidative status is scarce even though crucial for development of reproductive technologies and germplasm conservation. For these reasons, it is interesting to monitor sperm kinetics, bioenergetics, and oxidative status during sperm storage at
Ruo-Lan Li et al.
Oxidative medicine and cellular longevity, 2020, 3481758-3481758 (2020-07-23)
Zanthoxylum bungeanum pericarp is a commonly used herbal medicine in China with effects of anti-inflammatory and analgesic, improving learning and memory ability, while hydroxy-α-sanshool (HAS) is the most important active ingredient of Z. bungeanum pericarps. The purpose of this study
Chenxi Yan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 68, 104933-104933 (2020-07-12)
Indoor pollution with cooking oil fumes (COF) as one of the main components is closely related to ocular surface disorders. However, as the most abundant aldehyde in COF, the toxicity of trans, trans-2,4-decadienal (tt-DDE) on human cornea has not been
Xia Han et al.
Biomolecules & therapeutics, 23(4), 357-366 (2015-07-15)
Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced
Yuzhe Tang et al.
Molecular cancer therapeutics, 13(6), 1526-1536 (2014-04-02)
Prostate cancers at the late stage of castration resistance are not responding well to most of current therapies available in clinic, reflecting a desperate need of novel treatment for this life-threatening disease. In this study, we evaluated the anticancer effect
Chunchun Wang et al.
Journal of agricultural and food chemistry, 67(5), 1409-1417 (2019-01-03)
The study evaluated the effects of butyric acid, in the form of tributyrin on the oxidative stress, inflammation, and mitochondrial function in diquat-challenged pigs. Twenty-four weaned pigs were allocated to four treatments in a 2 × 2 factorial arrangement with
Adnan Khan et al.
Animals : an open access journal from MDPI, 10(6) (2020-06-25)
Heat stress in dairy cattle is recognized to compromise fertility by altering the functions of ovarian follicle-enclosed cells, e.g., oocyte and granulosa cells (GCs). Catalase is an antioxidant enzyme that plays a significant role in cellular protection against oxidative damage
Dipanwita Das Mukherjee et al.
Biochimica et biophysica acta. Molecular cell research, 1867(10), 118762-118762 (2020-06-06)
Microtubules, the key components of the eukaryotic cytoskeleton and mitotic spindle, are one of the most sought-after targets for cancer chemotherapy, especially due to their indispensible role in mitosis. Cervical cancer is a prevalent malignancy among women of developing countries
Melatonin regulates the autophagic flux via activation of alpha-7 nicotinic acetylcholine receptors.
Jae-Kyo Jeong et al.
Journal of pineal research, 59(1), 24-37 (2015-03-27)
Our previous study suggested that melatonin-mediated neuroprotective effects are related with the activation of autophagy. However, the mechanism of melatonin-mediated autophagic activation in prion-mediated mitochondrial damage is not reported. Alpha-7 nicotinic acetylcholine receptors (α7nAchR) is a member of nicotinic acetylcholine
Xiaosong Bu et al.
Neuropsychiatric disease and treatment, 13, 1633-1645 (2017-07-12)
Autistic spectrum disorder (ASD) is a neurodevelopmental disorder and has a high prevalence in children. Recently, mitochondrial oxidative stress has been proposed to be associated with ASD. Besides, SIRT1/PGC-1α signaling plays an important role in combating oxidative stress. In this
Polyana Lopes Benfica et al.
Pharmaceutical biology, 55(1), 1899-1908 (2017-06-24)
4-Nerolidylcatechol (4-NRC) has showed antitumor potential through apoptosis. However, its apoptotic mechanisms are still unclear, especially in leukemic cells. To evaluate the cytotoxic potential of 4-NRC and its cell death pathways in p53-null K562 leukemic cells. Cytotoxicity of 4-NRC (4.17-534.5 μM)
Weiqiang Zhang et al.
International journal of oncology, 53(6), 2409-2422 (2018-10-16)
Mammalian STE20-like kinase 1 (Mst1) is well recognized as a major tumor suppressor in cancer development, growth, metabolic reprogramming, metastasis, cell death and recurrence. However, the roles of Mst1 in non-small cell lung cancer (NSCLC) A549 cell phenotypic alterations remain to
Ting Liu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 128, 110221-110221 (2020-05-25)
Lung cancer is a leading cause of human death worldwide. Nevertheless, the outcome of present therapeutic options is still not satisfying. Engeletin (ENG, dihydrokaempferol 3-rhamnoside) is a flavanonol glycoside, showing anticancer activities in some tumors. But the exact molecular mechanism
Jinjuan Liu et al.
Nutrition and cancer, 73(1), 160-168 (2020-03-18)
Gastric cancer is one of the most common malignant tumors in the world, and prevention through diet is one of the ways to control. Houttuynia cordata thunb.(HCT) is a plant having medicine and food function, has many biological properties. However
Min-Yan Yang et al.
Journal of pharmacological sciences, 145(1), 105-114 (2020-12-29)
Brain microvascular endothelial cells (BMECs) dysfunction is related to the pathogenesis of neurovascular complication of diabetes mellitus that adversely lead to various CNS disorders. Mitoquinone (MitoQ) is a mitochondria targeted antioxidant that exerts multiple protective effects in many oxidative damage-related
Zhendong Zhao et al.
Molecules (Basel, Switzerland), 23(6) (2018-06-09)
Curcumin is acknowledged for its antioxidant, anti-inflammatory, anti-cancer, and wound-healing properties. However, the biological activity and the molecular mechanisms of T59, which is a new derivative of curcumin, are not fully understood. The present study was aimed to determine the
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