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Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities.

Journal of medicinal chemistry (2010-01-14)
Ma Angeles Castro, José Ma Miguel del Corral, Pablo A García, Ma Victoria Rojo, Janis de la Iglesia-Vicente, Faustino Mollinedo, Carmen Cuevas, Arturo San Feliciano
ABSTRACT

Several series of nonlactonic podophyllic aldehyde analogues were prepared and evaluated against several human tumor cell lines. They had different combinations of aldehyde, imine, amine, ester, and amide functions at C-9 and C-9' of the cyclolignan skeleton. All the compounds synthesized showed cytotoxicity levels in the microM range and below. Within the new series tested, compounds having an aldehyde or imine at C-9 and an ester at C-9' were the most potent, with GI(50) values in the nM range, some of them being several times more potent against HT-29 and A-549 carcinoma than against MB-231 melanoma cells. Cell cycle studies and analysis of the microtubule-disrupting capacity have demonstrated the existence of two different mechanisms of cell death induction for compounds with closely related structures.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Podophyllotoxin