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Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

Bioorganic & medicinal chemistry letters (2011-09-23)
Fadoua Bouchikhi, Fabrice Anizon, Reto Brun, Pascale Moreau
ABSTRACT

The biological activities of diversely substituted glycosyl-isoindigo derivatives against the causative agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis) are reported. Some of the compounds tested showed interesting activities with good selectivity indices, particularly against Trypanosoma brucei rhodesiense. These results suggested, for the first time, that glycosyl-isoindigo derivatives could be of interest for the discovery of new lead compounds to treat tropical diseases.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Podophyllotoxin
Sigma-Aldrich
Miltefosine, ≥98% (perchloric acid titration)