Prenatal exposures to perfluorinated chemicals and anthropometry at 7 years of age.

American journal of epidemiology (2013-07-05)
Camilla Schou Andersen, Chunyuan Fei, Michael Gamborg, Ellen A Nohr, Thorkild I A Sørensen, Jørn Olsen
ABSTRAKT

Fetal exposure to the perfluoroalkyl acids, perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA), has been associated with lower birth weight and lower weight and body mass index (weight (kg)/height (m)(2)) in early infancy. It is, however, unclear if exposure to prenatal PFOS and PFOA has a lasting influence on growth. We estimated the associations between the maternal plasma level of PFOS or PFOA and the children's body mass index, waist circumference, and risk of overweight at 7 years of age. A total of 1,400 women were randomly selected from the Danish National Birth Cohort among those who provided blood samples early in pregnancy and gave birth to liveborn singletons in 1996-2002. Weight and height information at 7 years was available for 811 children. Multiple linear and logistic regression models were used for analyses. Maternal PFOS and PFOA concentrations were overall inversely but nonsignificantly associated with the children's body mass index, waist circumference, and risk of overweight at 7 years of age. In conclusion, plasma levels of PFOS and PFOA in pregnant women did not seem to have any appreciable influence on their children's anthropometry at this point in childhood.

MATERIAŁY
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Sigma-Aldrich
Perfluorooctanoic acid, 95%
Sigma-Aldrich
Heptadecafluorooctanesulfonic acid solution, ~40% in H2O (T)
Supelco
Heptadecafluorooctanesulfonic acid solution, 100 μg/mL in methanol, analytical standard
Supelco
Pentadecafluorooctanoic acid, analytical standard
Supelco
Pentadecafluorooctanoic acid solution, 100 μg/mL in methanol, analytical standard
Sigma-Aldrich
Pentadecafluorooctanoic acid ammonium salt, ≥98.0% (NT)