Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer.

PloS one (2014-09-11)
Xiao-shan Li, Qing Xu, Xiang-yang Fu, Wei-sheng Luo
ABSTRAKT

Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with clinicopathological parameters and prognosis in gastric cancer. The levels of HSP60 and matrix metallopeptidase 9 (MMP-9) antigen was evaluated by immunohistochemistry in 223 gastric carcinoma samples. The association between HSP60 and MMP-9, clinicopathological parameters, and prognosis of gastric cancer was examined. The level of HSP60 protein was significantly associated with depth invasion, lymph node metastasis and stage of disease (all P<0.05). Both univariate and multivariate analyses revealed that HSP60 was an independent prognostic factor for both overall survival (OS) and recurrence-free survival (RFS) (both P<0.05). Furthermore, HSP60 overexpression was associated with a poor prognosis in patients with advanced gastric cancer in different risk groups. Moreover, HSP60 was significantly correlated with MMP-9 among 223 gastric cancer tissues (P<0.001). Patients who had HSP60 overexpression, in which tumor cells displayed high invasiveness, had poor OS and shorter RFS. HSP60 plays an important role on tumor aggressiveness and prognosis, and may act as a promising target for prognostic prediction.

MATERIAŁY
Numer produktu
Marka
Opis produktu

Sigma-Aldrich
Anti-MMP9 antibody produced in rabbit, IgG fraction of antiserum
Sigma-Aldrich
Anti-Matrix Metalloproteinase-9 antibody produced in goat, affinity isolated antibody
Sigma-Aldrich
Anti-MMP9 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution
Sigma-Aldrich
Anti-HSPD1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
Sigma-Aldrich
Anti-HSPD1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
Sigma-Aldrich
Monoclonal Anti-MMP9 antibody produced in mouse, clone 2H4, purified immunoglobulin, buffered aqueous solution
Sigma-Aldrich
Anti-HSPD1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Sigma-Aldrich
Monoclonal Anti-MMP9 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0539, purified immunoglobulin, buffered aqueous glycerol solution
Sigma-Aldrich
Monoclonal Anti-MMP9 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0538, purified immunoglobulin, buffered aqueous glycerol solution
Sigma-Aldrich
Rabbit anti-HSP60 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.
Sigma-Aldrich
Monoclonal Anti-MMP9 antibody produced in mouse, clone 5G3, ascites fluid
Sigma-Aldrich
Monoclonal Anti-MMP9 antibody produced in mouse, clone 5C3, ascites fluid
Sigma-Aldrich
Monoclonal Anti-MMP9 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0542, purified immunoglobulin, buffered aqueous glycerol solution

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.