≥90.0% (proton, NMR)
reaction type: Carbonylations
Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.
peptide synthesis: suitable
117-122 °C (lit.)
Looking for similar products? Visit Product Comparison Guide
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1B
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
N-Acylimidazoles were recognized in the early 1950s as reactive intermediates suitable for the acylation of amino compounds. The search for better coupling reagents than DCC led to the development of CDI (1,1’-carbonyldiimidazole) and related carbonylimidazoles.
Amide bonds are ubiquitous in both nature and industrial applications. They are vital to the structure and function of biological macromolecules and polymers. The importance of this functionality has resulted in numerous approaches to its formation, ranging from stoichiometric activation of carboxylic acids to more recent advances in catalytic amide bond formation.