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Biomaterials science, 8(1), 266-277 (2019-11-07)
Allotransplantation offers the potential to restore the anatomy and function of injured tissues and organs, but typically requires life-long, systemic administration of immunosuppressive drugs to prevent rejection, which can result in serious complications. Targeting the immunosuppressive drug to the graft...
Shigehito Osawa et al.
Biomacromolecules, 17(1), 354-361 (2015-12-20)
Improving the stability of polyplex micelles under physiological conditions is a critical issue for promoting gene transfection efficiencies. To this end, hydrophobic palisade was installed between the inner core of packaged plasmid DNA (pDNA) and the hydrophilic shell of polyplex...
Biological hydrogel synthesized from hyaluronic acid, gelatin and chondroitin sulfate by click chemistry.
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Oncoimmunology, 8(11), 1659095-1659095 (2019-10-28)
Chimeric antigen receptor (CAR) T cells have shown impressive therapeutic potential. Due to the lack of direct control mechanisms, therapy-related adverse reactions including cytokine release- and tumor lysis syndrome can even become life-threatening. In case of target antigen expression on...