396494

Aminoguanidine hydrochloride

≥98%

• Synonym(s): Guanylhydrazine hydrochloride
• Linear Formula: NH₂NHC(=NH)NH₂ · HCl
• CAS Number: 1937-19-5
• Molecular Weight: 110.55
• Beilstein: 3909606
• EC Number: 217-707-7
• MDL number: MFCD00039074
• PubChem Substance ID: 24864672
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: ≥98%
• form: solid
• mp: 162-166 °C (lit.)
• SMILES string: Cl.NNC(N)=N
• InChI: 1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
• InChI key: UBDZFAGVPPMTIT-UHFFFAOYSA-N

Description

General description

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Application

Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

Biochem/physiol Actions

Inhibits both constitutive and inducible nitric oxide synthetase.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H317 - H411
• Precautionary Statements: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Hazard Classifications: Aquatic Chronic 2 - Skin Sens. 1B
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves