602892

Sigma-Aldrich

Oxygen-18O2

99 atom % 18O, 99% (CP)

Linear Formula:
18O2
CAS Number:
Molecular Weight:
36.00
MDL number:
PubChem Substance ID:
NACRES:
NA.12

Quality Level

vapor density

1.11 (vs air)

isotopic purity

99 atom % 18O

assay

99% (CP)

application(s)

PET imaging: suitable

bp

−183 °C (lit.)

mp

−218 °C (lit.)

mass shift

M+4

SMILES string

[18O]=[18O]

InChI

1S/O2/c1-2/i1+2,2+2

InChI key

MYMOFIZGZYHOMD-XPULMUKRSA-N

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General description

Oxygen-18O2 is a naturally occurring stable isotope of oxygen. Natural abundance of 18O2 containing at least 99 atom % O-18.

Application

18O2 isotopic labelling was employed, in conjunction with time-of-flight secondary ion mass spectrometry, to characterize and elucidate the parts of the degradation mechanisms induced by molecular oxygen. Using 18O2 as a label, it is possible to study collagen degradation with this non-reutilized label and so avoid the large errors that are introduced by the recycling of other labels.

Packaging

500 mL in Sure-Pac™
1 L quantity is packaged in a 450 mL carbon steel lecture bottle with brass CGA 110/180 valve. Nominal gas pressure at 21ºC is 20 psig for 1 L. This pressure is slightly above atmospheric pressure. Care must be taken when extracting this product from the cylinder.
All gas volumes are quoted at Standard Temperature and Pressure (STP) and not at Normal Temperature and Pressure (NTP). One STP Liter is 7.7% more gas than one NTP Liter.

Recommended products

Brass hose adapter Z146811 or brass body mini gas regulator Z513539 is recommended for 500 mL Sure/Pac cylinder (U.S only). For 1 L cylinder, either stainless steel control valve Z146951 or Z187224 is recommended.
PTFE sealing washers GCA inlet size 180 Z146994
PTFE sealing washers CGA inlet size 110 Z146986

pictograms

Flame over circleGas cylinder

signalword

Danger

hazcat

Ox. Gas 1 - Press. Gas Compr. Gas

storage_class_code

2A - Gases

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Rachelle A S Lemke et al.
The Journal of biological chemistry, 295(29), 9786-9801 (2020-05-22)
Fatty acids play many important roles in cells and also in industrial processes. Furan fatty acids (FuFAs) are present in the lipids of some plant, fish, and microbial species and appear to function as second messengers in pathways that protect...
Catherine Fenselau et al.
Journal of proteome research, 8(5), 2140-2143 (2009-04-03)
Enzyme-catalyzed 18O2-labeling offers a universal strategy for uniform labeling of all peptides from any kind of proteins, including post-translationally modified proteins. It is applicable to clinical samples with unrivaled sensitivity. This review discusses strengths and limitations, and advocates the separation...
J A Molnar et al.
The Biochemical journal, 250(1), 71-76 (1988-02-15)
To explore the effects of growth retardation, caused by restricted protein intake, on collagen turnover in the whole skin, Sprague-Dawley rats (n = 20) were labelled with 18O2 and fed on either an adequate (18%) or a low (3%) lactalbumin...
Sui So et al.
Physical chemistry chemical physics : PCCP, 16(45), 24954-24964 (2014-10-18)
β-Hydroxyperoxyl radicals are formed during atmospheric oxidation of unsaturated volatile organic compounds such as isoprene. They are intermediates in the combustion of alcohols. In these environments the unimolecular isomerization and decomposition of β-hydroxyperoxyl radicals may be of importance, either through...
Related Content
Labeled isotopes used as target materials in imaging have provided insights into the various mechanisms of human physiology and have lead to treatments for diseases. Water-18O is used for the production of 18F radionuclides, such as 18FDG (Fluoro-deoxyglucose). 18FDG used in PET and with other imaging technologies, such as CT/SPECT, has led to the diagnosis and treatment of a wide range of diseases, including lung, liver, and brain tumors, epilepsy, and Alzheimer’s.
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