856525

Sigma-Aldrich

2-Methyl-1,2-di-3-pyridyl-1-propanone

96%

Synonym(s):
Su-4885, Metyrapone
Empirical Formula (Hill Notation):
C14H14N2O
CAS Number:
Molecular Weight:
226.27
Beilstein/REAXYS Number:
163023
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

96%

mp

52-55 °C (lit.)

SMILES string

CC(C)(c1cccnc1)C(=O)c2cccnc2

InChI

1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3

InChI key

FJLBFSROUSIWMA-UHFFFAOYSA-N

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Application

2-Methyl-1,2-di-3-pyridyl-1-propanone inhibits the biosynthesis of corticosterone by blocking the conversion of deoxycorticosterone to corticosterone. It is widely used in adrenocortical-related clinical studies.

Packaging

250 mg in glass insert
1 g in glass bottle

pictograms

Exclamation mark

signalword

Warning

hazcat

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption?screening of 30 selected chemicals in the human H295R cell model.
Uller?s E, et al.
Journal of Applied Toxicology, 28(8), 1045-1053 (2008)
The relationship between adrenocortical function and Hsp70 expression in socially isolated Japanese quail.
Soleimani AF, et al.
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 161(2), 140-144 (2012)
Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach.
Rijk JCW, et al.
Chemical Research in Toxicology, 25(8), 1720-1731 (2012)
Therese Koal et al.
The Journal of steroid biochemistry and molecular biology, 129(3-5), 129-138 (2012-01-03)
In order to overcome many limitations of immunoassays, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has the potential to find its place in the clinical laboratory medicine for quantification of steroid hormones. A prerequisite for the application of a new...
Xavier Belda et al.
Hormones and behavior, 62(4), 515-524 (2012-09-19)
A single exposure to some severe stressors causes sensitization of the hypothalamic-pituitary-adrenal (HPA) response to novel stressors. However, the putative factors involved in stress-induced sensitization are not known. In the present work we studied in adult male rats the possible...

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