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Diisopropylcarbodiimide solution

1 M in dichloromethane

Linear Formula:
CAS Number:
MDL number:



reaction suitability

reaction type: Coupling Reactions


1 M in dichloromethane

refractive index

n/D 1.4251




peptide synthesis



InChI key


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General description

DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.


Valuable reagent offered as a solution in dichloromethane for more convenient handling.
  • Alternative to dicyclohexylcarbodiimide in peptide synthesis.
  • Coupling reagent for peptide syntheses.
  • DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.

Signal Word


Hazard Classifications

Acute Tox. 2 Inhalation - Carc. 2 - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids



Flash Point(F)

91.4 °F

Flash Point(C)

33 °C

Certificate of Analysis

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Certificate of Origin

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More documents

Quotes and Ordering

Cody L Gilleland et al.
Genetics, 201(1), 39-46 (2015-07-15)
A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of genetic
Tianyi Zhang et al.
Journal of cell science, 128(15), 2938-2950 (2015-06-21)
The v-ATPase is a fundamental eukaryotic enzyme that is central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well documented, our knowledge of mechanisms that regulate v-ATPase activity is limited. Here, we report that
P J Weber et al.
Bioorganic & medicinal chemistry letters, 8(6), 597-600 (1999-01-01)
A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology, pharmacology, drug targeting and medicinal chemistry. We show, that 4(5)-carboxyfluorescein is much more efficient than the hitherto predominantly utilized reagents
Stéphane Chantepie et al.
PloS one, 10(7), e0133140-e0133140 (2015-07-29)
Do all traits within an organism age for the same reason? Evolutionary theories of aging share a common assumption: the strength of natural selection declines with age. A corollary is that additive genetic variance should increase with age. However, not
Qiu Dai et al.
Journal of the American Chemical Society, 127(22), 8008-8009 (2005-06-02)
Gold nanoparticles with a single carboxylic acid group on the surface were prepared from a solid phase place exchange reaction and then coupled to polylysine using an in situ activation agent, diisopropylcarbodiimide (DIPCDI). The covalent amide bond linkage between the

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