Merck
All Photos(4)

H1384

Sigma-Aldrich

Hypotaurine

≥98% (TLC)

Synonym(s):
2-Aminoethanesulfinic acid
Empirical Formula (Hill Notation):
C2H7NO2S
CAS Number:
Molecular Weight:
109.15
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

≥98% (TLC)

color

white to off-white

solubility

H2O: 100 mg/mL

SMILES string

NCCS(O)=O

InChI

1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)

InChI key

VVIUBCNYACGLLV-UHFFFAOYSA-N

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Application

Hypotaurine has been used as a supplement in fertilization medium (Fert- tyrode albumin lactate pyruvate (TALP)), which used in in-vitro fertilization and evaluation of embryo development. It is also used as a H2S scavenger.

Packaging

10 mg in glass bottle
100, 250 mg in poly bottle
1 g in poly bottle

Biochem/physiol Actions

Hypotaurine, a cystamine analog, is the precursor for taurine synthesis. It can act as an antioxidant and singlet oxygen scavenger, thereby protecting cells from oxidative damage. Hypotaurine is reported to play an important role in the maintenance and stimulation of sperm motility and also in vitro fertilization and embryo development.
Antioxidant that binds hydroxyl radicals. Endogenous inhibitory neuromodulator that is blocked by strychnine and picrotoxin. Inhibits the Na2+-dependent transport of GABA and β-alanine. It is a degradation product of cysteine and a precursor of taurine.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H1384.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

The Significance of hydrogen sulfide for Arabidopsis seed germination.
Baudouin E, et al.
Frontiers in Plant Science, 7, 930-930 (2016)
M M Mahadevan et al.
Fertility and sterility, 43(2), 263-267 (1985-02-01)
Removal of cumulus may increase the chance of fertilization in patients with sperm antibodies, may facilitate fertilization in vitro with a small number of spermatozoa, and is necessary for microsurgical injection procedures in vitro. The aim of this study was
Effect of hypotaurine on in vitro fertilization and production of term offspring from in vitro-fertilized ova of the Japanese field vole, Microtus montebelli.
Wakayama T
Biology of Reproduction, 54(3), 625-630 (1996)
Andrea Carenzo et al.
Cells, 9(8) (2020-08-07)
Oral premalignant lesions (OPLs) represent the most common oral precancerous conditions. One of the major challenges in this field is the identification of OPLs at higher risk for oral squamous cell cancer (OSCC) development, by discovering molecular pathways deregulated in
Ultrastructural and immunohistochemical characterization of the bovine epiblast.
Vejlsted M, et al.
Biology of Reproduction, 72(3), 678-686 (2005)

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