Merck
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KITALYSIS-CN

Sigma-Aldrich

KitAlysis High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

Synonym(s):
Amination Screening Kit, Buchwald-Hartwig Amination
NACRES:
NA.22

reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

storage temp.

room temp

Application

Screening kit for CN (Buchwald-Hartwig) cross-coupling reaction. There are four possible screens that can be run based upon the user′s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.
Two Solvents, Weak Base (Cs2CO3)
Two Solvents, Strong Base (NaOt-Bu)
One Solvent (Dioxane), Two Bases
One Solvent (DMAc), Two Bases
Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains
  • 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
  • 2 bases (NaOt-Bu and Cs2CO3)
  • 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
  • 2 substrate reaction vials with stir bars
  • 1 internal standard
  • 4 reaction block replacement films

this protocol

Best when used with KitAlysis Benchtop Inertion Box
and 24-well Reaction Block
(sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists
  • Easily run 24-microscale reaction in parallel
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit Components Only

Product No.
Description

  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Kit Components Also Available Separately

Product No.
Description
SDS

  • 900634N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mL

  • 9006401,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mL

  • 702706Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mL

  • 747130Josiphos SL-J009-1 Pd G3 5 µmol

  • 753009SPhos Pd G2 5 µmol

  • 753246RuPhos Pd G2 5 µmol

  • 756482P(t-Bu)3 Pd G2 5 µmol

  • 761605BrettPhos Pd G3, 98% 5 µmol

  • 762229tBuXPhos Pd G3, 98% 5 µmol

  • 763004CPhos Pd G3, 95% 5 µmol

  • 763039XantPhos Pd G3, 95% 5 µmol

  • 763381XPhos Pd G3, 98%, 1:1 MTBE adduct 5 µmol

  • 792357MorDalphos Pd G3 5 µmol

  • 804959DavePhos-Pd-G3, 95% 5 µmol

  • 804967rac-BINAP-Pd-G3, 95% 5 µmol

See All (15)

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral

Supplementary Hazards

Storage Class Code

4.2 - Pyrophoric and self-heating hazardous materials

WGK

WGK 3

Flash Point(F)

-4.0 °F - closed cup

Flash Point(C)

-20 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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