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890890C

Avanti

18:1 TAP (DOTAP)

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt), chloroform

Empirical Formula (Hill Notation):
C42H80NO4Cl
CAS Number:
Molecular Weight:
698.54
NACRES:
NA.25

packaging

pkg of 1 × 2.5 mL (890890C-25mg)
pkg of 2 × 20 mL (890890C-1g)
pkg of 2 × 4 mL (890890C-200mg)
pkg of 5 × 4 mL (890890C-500mg)

manufacturer/tradename

Avanti Polar Lipids 890890C

concentration

10 mg/mL (890890C-25mg)
25 mg/mL (890890C-1g)
25 mg/mL (890890C-200mg)
25 mg/mL (890890C-500mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]

Application

18:1 TAP (DOTAP) has been used in the preparation of liposome-supported bilayers.

Biochem/physiol Actions

18:1 TAP (DOTAP) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP(1,2-dioleoyl-3-trimethylammonium-propane). 18:1 TAP (DOTAP) mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

5 mL Clear Glass Sealed Ampule (890890C-200mg)
5 mL Clear Glass Sealed Ampule (890890C-25mg)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (890890C-1g)
5 mL Clear Glass Sealed Ampule (890890C-500mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
Wen Xiao et al.
Molecular pharmaceutics, 17(1), 229-238 (2019-11-26)
Eukaryotic translation initiation factors 3i (eIF3i) is a proto-oncogene that is overexpressed in various tumors, reducing its expression by eIF3i shRNA is a promising strategy to inhibit tumor growth or metastasis. Tumor cell is the target of eIF3i shRNA so
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
Dengler EC, et al.
J. Controlled Release, 168(2), 209-224 (2013)
Xuejuan Ma et al.
Langmuir : the ACS journal of surfaces and colloids, 35(49), 16304-16311 (2019-11-09)
Aggregation-induced emission (AIE) is a powerful method to produce fluorescence for a diverse range of applications. While most previous work induced aggregation by change of solvent, ionic strength, pH, or self-assembly, we herein explored adsorption-induced aggregation using 4,4'-(hydrazine-1,2-diylidene bis(methanylylidene)) bis(3-hydroxybenzoic

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