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18:1 TAP (DOTAP)

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt), powder

Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:




pkg of 1 × 1 g (890890P-1g)
pkg of 2 × 100 mg (890890P-200mg)
pkg of 5 × 100 mg (890890P-500mg)
pkg of 1 × 25 mg (890890P-25mg)


Avanti Polar Lipids 890890P

shipped in

dry ice

storage temp.


SMILES string



18:1 TAP (DOTAP) has been used in chloroform solutions to form dry film in the preparation of cationic liposomes. It has also been used in standard stock solution used for the preparation of cationic liposomes.

Biochem/physiol Actions

DOTAP (1,2-dioleoyl-3-trimethylammonium-propane) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).


5 mL Clear Glass Sealed Ampule (890890P-200mg)
5 mL Clear Glass Sealed Ampule (890890P-500mg)
5 mL Clear Glass Sealed Ampule (890890P-25mg)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (890890P-1g)

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Analysis of cationic liposomes by reversed-phase HPLC with evaporative light-scattering detection
Zhong Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 51(4), 947-951 (2010)
Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
Cationic liposomes induce cytotoxicity in HepG2 via regulation of lipid metabolism based on whole-transcriptome sequencing analysis
Li Y, et al.
BMC Pharmacology & Toxicology, 19(1), 43-43 (2018)
DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes
Kim BK, et al.
Biochimica et Biophysica Acta - Biomembranes, 1848(10), 1996-2001 (2015)

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