1.00263

Formic acid

98-100%, EMPROVE^® ESSENTIAL

• Synonym(s): Formic acid, Methanoic acid, Formylic acid
• Linear Formula: HCOOH
• CAS Number: 64-18-6
• Molecular Weight: 46.03
• Beilstein: 1209246
• MDL number: MFCD00003297
• EC Index Number: 200-579-1

Properties

• vapor density: 1.6 (vs air)
• Quality Level: 500
• vapor pressure: 44.8 mmHg ( 20 °C)
• product line: EMPROVE^® ESSENTIAL
• Assay: ≥98% (alkalimetric)
• form: liquid
• autoignition temp.: 1004 °F
• expl. lim.: 12-38 % (v/v); 57 %
• concentration: 98-100%
• technique(s): API processing | polymorph screening: suitable; API processing | salt formation: suitable
• refractive index: n20/D 1.370 (lit.)
• pH: 2.2 (20 °C, 10 g/L in H₂O)
• bp: 100-101 °C (lit.); 101 °C/1013 hPa
• mp: 8.2-8.4 °C (lit.)
• transition temp: flash point 49.5 °C
• density: 1.22 g/mL at 25 °C (lit.)
• anion traces: chloride (Cl^-): ≤0.001%; sulfate (SO₄^2-): ≤0.004%; sulfite (SO₃^2-): ≤0.002%
• cation traces: As: ≤0.0003%; Cu: ≤0.002%; Pb: ≤0.001%; Zn: ≤0.002%; heavy metals (as Pb): ≤0.0005%
• application(s): liquid formulation; pharmaceutical
• storage temp.: 15-25°C
• SMILES string: OC=O
• InChI: 1S/CH2O2/c2-1-3/h1H,(H,2,3)
• InChI key: BDAGIHXWWSANSR-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Formic acid can be used as acidifying agent and buffer component in a variety of pharmaceutical formulations and processes.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS05,GHS06
• Signal Word: Danger
• Hazard Statements: H226 - H302 - H314 - H331
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A
• Supplementary Hazards: EUH071
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 121.1 °F
• Flash Point(C): 49.5 °C