1.10110

2-[4-(2-Hydroxyethyl)-1-piperazinyl]-ethanesulfonic acid

Buffer substance HEPES EMPROVE^® EXPERT

• Synonym(s): HEPES, 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)
• Empirical Formula (Hill Notation): C₈H₁₈N₂O₄S
• CAS Number: 7365-45-9
• Molecular Weight: 238.30
• Beilstein: 883043
• MDL number: MFCD00006158
• EC Index Number: 230-907-9

Properties

• Quality Level: 500
• product line: EMPROVE^® EXPERT
• potency: >2000 mg/kg LD₅₀, oral (Rat)
• technique(s): API processing | cocrystal formation: suitable
• pH: 5.0-5.5 (20 °C, 100 g/L in H₂O)
• useful pH range: 6.8-8.2
• pKa (25 °C): 7.5
• mp: 212.6 °C
• solubility: 703.6 g/L
• density: 1.44 g/cm³ at 20 °C
• bulk density: 560 kg/m³
• storage temp.: −20°C
• SMILES string: OCCN1CCN(CC1)CCS(O)(=O)=O
• InChI: 1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)
• InChI key: JKMHFZQWWAIEOD-UHFFFAOYSA-N

Description

General description

Our SAFC^® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE^® Program, our raw materials are offered with EMPROVE^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable