19-137

Sodium Butyrate

For use as a histone deacetylase inhibitor.

• Synonym(s): Butyric acid sodium salt
• eCl@ss: 32160405
• NACRES: NA.41

Properties

• Quality Level: 100
• form: liquid
• manufacturer/tradename: Upstate^®
• technique(s): activity assay: suitable (histone deacetylase (HDAC))
• shipped in: wet ice

Description

Application

Sodium Butyrate has been used:

• to inhibit histone deacetylase (HDAC) and study its effect on fibroblast growth factor 21 (FGF21) expression in liver
• to inhibit deacetylase activity in embryonic stem (ES) cells to determine if the enzymatic activity of the mSin3A-HDAC complex is essential for Nanog expression
• as a reagent during tissue homogenization
• as a supplement in chromatin immunoprecipitation (ChIP) dilution buffer

Packaging

10 mL

Biochem/physiol Actions

Sodium Butyrate is a short-chain fatty acid and a histone deacetylase inhibitor. It protects dopaminergic neuronal cells from α-synuclein mediated transcriptional deregulation and DNA damage, maybe by enhancing the expression of DNA-repair genes. Sodium butyrate may promote the production of foreign proteins such as erythropoietin, tissue plasminogen activator, antibody, and nitric oxide synthase in recombinant Chinese hamster ovary (rCHO) cell cultures. But, the higher concentration of sodium butyrate in rCHO cell cultures may also exhibit a cytotoxic effect on cell growth by inducing apoptosis. Sodium Butyrate prevents the growth of cancer cells by downregulating the thioredoxin 1 (Trx1) expression, stimulating reactive oxygen species (ROS) production, and inhibiting cell proliferation and migration of various carcinoma cells including colorectal cancer (CRC).

Physical form

CH₃CH₂CH₂COONa

Storage and Stability

1 year at 4°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable