370654

PKG Inhibitor

The PKG Inhibitor controls the biological activity of PKG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): PKG Inhibitor, Protein Kinase G Inhibitor, RKRARKE
• Empirical Formula (Hill Notation): C₃₈H₇₄N₁₈O₁₀
• Molecular Weight: 943.11

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A more specific, reversible, and substrate competitive inhibitor of protein kinase G (K_i = 86 µM) relative to protein kinase A (K_i = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser³² to Ala³²) of histone H2B (amino acids 29-35).

A specific, reversible, and substrate competitive inhibitor of PKG (K_i = 86 µM) relative to PKA (K_i = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser³² to Ala³²) of histone H2B (amino acids 29-35).

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target K_i: 86 µM against protein kinase G

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH

Other Notes

Glass, D.B., et al. 1983. Biochem. J.213, 159.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable