567430

Sodium Butyrate

A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway.

• Synonym(s): Sodium Butyrate, Butyric Acid, Na, NaB, HDAC Inhibitor V
• Empirical Formula (Hill Notation): C₄H₇NaO₂
• CAS Number: 156-54-7
• Molecular Weight: 110.09
• MDL number: MFCD00002816

Properties

• Quality Level: 200
• Assay: ≥98% (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 2 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
• InChI key: MFBOGIVSZKQAPD-UHFFFAOYSA-M

Description

General description

A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca²⁺ from intracellular stores. Reduces histamine-induced calcium mobilization in C6 glioma cells. Down-regulates the activity of the serine/threonine protein kinase casein kinase II in HT29 cells.

A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca²⁺ from intracellular stores. Downregulates the activity of serine/threonine protein kinase casein kinase II in HT29 cells.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Induce apoptosis

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ou, H.C., et al. 1997. Neuroreport 8, 1375.
Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
Krupitza, G., et al. 1995. Carcinogenesis16, 1199.
Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun.195, 31.
Hague, A., et al. 1993. Int. J. Cancer55, 498.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 - H315 - H319
• Precautionary Statements: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable