All Photos(3)

8.17061

SAFC

TWEEN® 80 (Polysorbate)

EMPROVE® ESSENTIAL Ph Eur,JP,NF

Synonym(s):
POE (20) sorbitan monooleate, TWEEN® 80, Polyoxyethylenesorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polysorbate 80
CAS Number:
MDL number:
EC Index Number:
500-019-9

Quality Level

Agency/Method

JP
NF
Ph. Eur.

vapor pressure

<1.33 hPa

product line

EMPROVE® ESSENTIAL

potency

42200 mg/kg LD50, oral (Rat)

pH

5-7 (20 °C, 50 g/L in H2O)

kinematic viscosity

300-500 cSt(25 °C)

bp

>100 °C/1013 hPa

transition temp

flash point >149 °C

density

1.07 g/cm3 at 25 °C

Featured Industry

Pharmaceutical
biopharma process and formulation
liquid formulation
ophthalmics
parenterals
semi-solid formulation
solid formulation
solubility enhancement

storage temp.

15-25°C

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Polysorbate 80 is used as surfactant in a variety of liquid formulations and acts e.g. as emulsifying, solubilizing and wetting agent.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK Germany

WGK 1

Flash Point F

235.4 °F - closed cup

Flash Point C

> 113 °C - closed cup

Certificate of Analysis

Certificate of Origin

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

Free of charge - Sign in to download

Quality Management Dossier

Available by subscription or for a fee

Operational Excellence Dossier

Available by subscription or for a fee

Learn more about the benefits an Emprove® Program subscription can provide
Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

Related Content

Culture Media for Compendial Methods

Learn more about our culture media portfolio for microbial examination of non-sterile products, fully compliant with the harmonized Pharmacopoeia.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service