Merck
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AB2283

Sigma-Aldrich

Anti-Tbr2 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):
eomesodermin (Xenopus laevis) homolog, eomesodermin homolog (Xenopus laevis), t box, brain, 2
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

technique(s)

immunohistochemistry: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

Gene Information

human ... EOMES(8320)
mouse ... Eomes(13813)

General description

Tbr2 (a T-domain transcription factor) is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Trb2 has been shown to play a role in the development of the neocortex and functions in the differentiation pathway of radial glia to postmitotic projection neuron.

Specificity

This antibody recognizes Tbr2.

Immunogen

Epitope: Internal Domain
KLH-conjugated linear peptide corresponding to mouse Tbr2.

Application

This Anti-Tbr2 Antibody is validated for use in IH for the detection of Tbr2.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Quality

Evaluated by Immunohistochemistry of human brain tissue.

Immunohistochemistry Analysis: A 1:300 dilution of Anti-Tbr2 antibody from a previous lot detected Tbr2 in mouse and human brain tissue.

Physical form

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Affinity purified

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human Brain Tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Quality

Enter Lot Number to search for Certificate of Quality (COQ).

A human stem cell model of early Alzheimer's disease pathology in Down syndrome.
Shi, Yichen, et al.
Science Translational Medicine, 4, 124ra29-124ra29 (2012)
Aiwu Cheng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(32), 10752-10762 (2010-08-13)
Monoamine neurotransmitters play major roles in regulating a range of brain functions in adults and increasing evidence suggests roles for monoamines in brain development. Here we show that mice lacking the monoamine metabolic enzymes MAO A and MAO B (MAO
Melanie Schoof et al.
Acta neuropathologica communications, 7(1), 199-199 (2019-12-07)
CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase (KAT) activity. Germline mutations within the CBP gene are known to cause Rubinstein-Taybi syndrome (RSTS), a developmental disorder characterized
Livia Goto-Silva et al.
BMC developmental biology, 19(1), 3-3 (2019-03-08)
Organoid cultivation in suspension culture requires agitation at low shear stress to allow for nutrient diffusion, which preserves tissue structure. Multiplex systems for organoid cultivation have been proposed, but whether they meet similar shear stress parameters as the regularly used
Nathalie Saurat et al.
Neural development, 8, 14-14 (2013-07-31)
During cerebral cortex development, multipotent neural progenitor cells generate a variety of neuronal subtypes in a fixed temporal order. How a single neural progenitor cell generates the diversity of cortical projection neurons in a temporal sequence is not well understood.

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