SFTPC, also known as SFTP2 and Pulmonary surfactant-associated protein C, is a complex mixture of phospholipids and proteins secreted from airway epithelial cells (type II cells) in alveoli which reduces the surface tension at the alveolar air liquid interface, providing alveolar stability necessary for normal ventilation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP A (28 - 36 kDa) and SP D (43 kDa) are collagenous carbohydrate binding proteins, whereas SP B (8 - 9 kDa) and SP C (4 kDa) are non collagenous hydrophobic proteins. SP C is a fragment of a much larger precursor protein of 21 kDa. The precursor contains an exceedingly hydrophobic region of 34 amino acids that comprises most of the mature SP C, and a unique poly-valine domain.
KLH-conjugated linear peptide corresponding to the N-terminus of human SFTPC.
Detect SP-C using this rabbit polyclonal antibody, Anti-SFTPC Antibody validated for use in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected SFTPC in human lung tissue.
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Evaluated by Western Blotting in rat lung tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected SFTPC in 10 µg of rat lung tissue lysate.
~20 kDa observed
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Rat lung tissue lysate
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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