383376

Sigma-Aldrich

Potassium antimonyl tartrate trihydrate

ACS reagent, ≥99%

Synonym(s):
Antimony potassium tartrate trihydrate, Tartar emetic
Empirical Formula (Hill Notation):
C8H4K2O12Sb2 · 3H2O
CAS Number:
Molecular Weight:
667.87
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

grade

ACS reagent

assay

≥99%
99.0-103.0%

impurities

≤0.020 meq/g Titr. acid or base

loss

≤2.7% loss on drying

mp

≥300 °C (lit.)

solubility

water: soluble

cation traces

As: ≤0.015%

SMILES string

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4

InChI key

WBTCZEPSIIFINA-UHFFFAOYSA-J

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Potassium antimonyl tartrate trihydrate is a metalloid salt in which the antimony is in trivalent state (SbIII). Potassium antimonyl tartrate (PAT) is an antiparasitic agent predominantly used for treating infections caused by the parasite Leishmania. Its antiangiogenic and antitumor properties has been investigated in nonsmall-cell lung cancer (NSCLC) cells. Studies in Chinese hamster ovary cells show that it may prevent the repair of DNA double strand breaks (DSBs) caused by γ-irradiation.

Application

Potassium antimonyl tartrate trihydrate has been used in the dose-inhibition experiments to evaluate the dose-inhibition curves of antimony-based antileishmanial compounds against Leishmania promastigotes in medium 199.
Potassium antimonyl tartrate trihydrate may be used to prepare antimony (Sb(III)) stock solution in deionized water (100mg/L). It may also be employed in the spectrophotometric determination of total phosphorus in dry sediments.

Packaging

100 g in poly bottle

pictograms

Skull and crossbonesEnvironment

signalword

Danger

hazcat

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

storage_class_code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

v
Vijayaraghavan K and Balasubramanian R.
Industrial & Engineering Chemistry Research, 50(17), 9864-9869 (2011)
Nutrient contents in bottom sediment samples from a southern Brazilian microbasin.
Antunes M, et al.
Environmental earth sciences, 69(3), 959-968 (2013)
Zahra Faghiri et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(8), 2780-2789 (2009-04-15)
Schistosomes are parasitic platyhelminths that constitute an important public health problem globally. Infection is characterized by the presence of adult worms within the vasculature of their hosts, where they can reside for many years. The worms are covered by an...
Susan Wyllie et al.
Biochemical pharmacology, 71(3), 257-267 (2005-12-02)
Trivalent antimonial compounds (Sb(III)), originally used in the treatment of leishmaniasis, are now being proposed as a novel therapy for acute promyelocytic leukaemia (APL). Here, we examine the effects of Sb(III) and pentavalent antimonial drugs (Sb(V)) on glutathione homeostasis, oxidative...
Mostafa K Mohamed et al.
Journal of medical virology, 78(9), 1185-1189 (2006-07-19)
The origin of the hepatitis C virus (HCV) epidemic in Egypt has been attributed to intravenous schistosomiasis treatment in rural areas in the 1960s to 70s. The objective of this study was to estimate the HCV-related morbidity in a rural...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service