410225

Glycine

ACS reagent, ≥98.5%

• Synonym(s): Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: NH₂CH₂COOH
• CAS Number: 56-40-6
• Molecular Weight: 75.07
• Beilstein: 635782
• EC Number: 200-272-2
• MDL number: MFCD00008131
• eCl@ss: 32160406
• PubChem Substance ID: 24865701
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 200
• Assay: ≥98.5%
• form: crystals; powder or granules
• impurities: H₂SO₄, passes test (darkened); Hydrolyzable subsances, passes test
• ign. residue: ≤0.1%
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• anion traces: chloride (Cl^-): ≤0.005%; sulfate (SO₄^2-): ≤0.005%
• cation traces: NH₄⁺: ≤0.005%; heavy metals: ≤0.002% (by ICP)
• application(s): peptide synthesis
• SMILES string: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChI key: DHMQDGOQFOQNFH-UHFFFAOYSA-N
• Gene Information: rat ... Grin2a(24409)

Description

Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents. It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.

Biochem/physiol Actions

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves