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436143

Sigma-Aldrich

Sodium dodecyl sulfate

ACS reagent, ≥99.0%

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Synonym(s):
Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate
Linear Formula:
CH3(CH2)11OSO3Na
CAS Number:
Molecular Weight:
288.38
Beilstein:
3599286
EC Number:
MDL number:
eCl@ss:
39093306
PubChem Substance ID:
NACRES:
NA.21

grade

ACS reagent

Quality Level

description

anionic
62

Assay

≥99.0%

form

solid

mol wt

288.38 g/mol

impurities

≤0.06 meq/g Titr. Base
≥96.0% fatty alcohols
<4.0% unsulfated alcohols

loss

≤1.0% loss on drying

mp

204-207 °C (lit.)

solubility

H2O: soluble 1 gm in 10 ml (opalescent solution)

cation traces

heavy metals (as Pb): ≤0.002%

λ

3 %H2O reference

UV absorption

λ: 220-350 nm Amax: ≤0.1

HLB

40

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

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1 of 4

This Item
71729L5750RDD021
Sodium dodecyl sulfate ACS reagent, &#8805;99.0%

Sigma-Aldrich

436143

Sodium dodecyl sulfate

Essential Grade
Sodium dodecyl sulfate &#8805;98.0% (GC)

Sigma-Aldrich

71729

Sodium dodecyl sulfate

-
Sodium dodecyl sulfate 92.5-100.5% based on total alkyl sulfate content basis

Sigma-Aldrich

L5750

Sodium dodecyl sulfate

-
Sodium dodecyl sulfate anhydrous, free-flowing, Redi-Dri&#8482;, ACS reagent, &#8805;99.0%

Sigma-Aldrich

RDD021

Sodium dodecyl sulfate

Essential Grade
description

anionic, 62

description

anionic

description

anionic

description

anionic

assay

≥99.0%

assay

≥98.0% (GC)

assay

92.5-100.5% based on total alkyl sulfate content basis

assay

≥99.0%

form

solid

form

rod

form

-

form

-

mol wt

288.38 g/mol

mol wt

micellar avg mol wt 18,000

mol wt

288.38 g/mol

mol wt

288.38 g/mol

impurities

≤0.06 meq/g Titr. Base, ≥96.0% fatty alcohols, <4.0% unsulfated alcohols

impurities

-

impurities

-

impurities

≤0.06 meq/g Titr. Base, ≤4.0% unsulfated alcohols, ≥96.0% fatty alcohols

General description

Sodium dodecyl sulfate (SDS), also known as sodium lauryl sulfate, is a versatile anionic surfactant with a broad range of applications in cell biology, biochemistry, and various industries. Its amphiphilic nature, characterized by a hydrophobic hydrocarbon tail and a hydrophilic sulfate head group, makes it an effective detergent capable of solubilizing and denaturing proteins, lipids, and other hydrophobic molecules.

In protein biochemistry, SDS plays a pivotal role in protein extraction and SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis). Its ability to denature proteins by disrupting their secondary and tertiary structures allows for their uniform migration through a polyacrylamide gel matrix based on their molecular weight. This technique, SDS-PAGE, has become an indispensable tool for analyzing protein size and purity.

Beyond protein analysis, SDS also finds applications in nucleic acid extraction and hybridization techniques. Its detergent properties aid in the lysis of cells and the solubilization of cellular components, facilitating the extraction of DNA and RNA. This makes SDS a valuable reagent in various molecular biology protocols, including PCR (polymerase chain reaction) and Southern blotting. Sodium dodecyl sulfate stands as a versatile and widely used surfactant with a diverse range of applications due to its ability to solubilize, denature, and separate biological molecules for cell biology and biochemical research.

Application

Sodium dodecyl sulfate was used as a test compound for studying that whether Bacillus amyloliquefaciens KPS46 can induce priming, signaling, protein production as well as systemic protection in soybean (Glycine max L.) against several diseases.
Anionic detergent

Biochem/physiol Actions

Sodium dodecyl sulfate (SDS) is an anionic detergent that can form complexes with protein through hydrophobic interactions. Studies have reported that the hydrodynamic functions of protein-SDS complexes are governed by the length of their polypeptide chains. Thus, SDS-based electrophoretic techniques can separate protein molecules based on their molecular weights. Additionally, SDS can solubilize cell membranes and can extract membrane-bound proteins.

Features and Benefits

  • Highly versatile surfactant for your molecular biology and biochemical research
  • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 2

Flash Point(F)

338.0 °F

Flash Point(C)

170 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Customers Also Viewed

Slide 1 of 6

1 of 6

Priming, signaling, and protein production associated with induced resistance by Bacillus amyloliquefaciens KPS46.
Natthiya Buensanteai
World Journal of Microbiology & Biotechnology, 25 (2009)
The gross conformation of protein-sodium dodecyl sulfate complexes.
J A Reynolds et al.
The Journal of biological chemistry, 245(19), 5161-5165 (1970-10-10)
K Fujimoto
Journal of cell science, 108 ( Pt 11), 3443-3449 (1995-11-01)
We propose a new electron microscopic method, the sodium dodecylsulphate (SDS)-digested freeze-fracture replica labeling technique, to study the two-dimensional distribution of integral membrane proteins in cellular membranes. Unfixed tissue slices were frozen with liquid helium, freeze-fractured, and replicated in a
Shane Stegeman et al.
Endocrine-related cancer, 22(2), 265-276 (2015-02-12)
The oncogene MDM4, also known as MDMX or HDMX, contributes to cancer susceptibility and progression through its capacity to negatively regulate a range of genes with tumour-suppressive functions. As part of a recent genome-wide association study it was determined that
Kazuya Ishikawa et al.
Nature communications, 5, 5430-5430 (2014-11-13)
Pathogen effector proteins are delivered to host cells to suppress plant immunity. However, the mechanisms by which effector proteins function are largely unknown. Here we show that expression of XopP(Xoo), an effector of rice pathogen Xanthomonas oryzae pv. oryzae, in

Protocols

Single-walled Carbon Nanotubes: Exfoliation and Debundling Procedure

In a typical dispersion procedure, a surfactant is adsorbed on the single-walled carbon nanotubes (SWCNTs) surface and the solution is sonicated, resulting in the debundling or exfoliation of the carbon nanotubes.

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