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439126

Sigma-Aldrich

Acetone

suitable for HPLC, ≥99.9%

Linear Formula:
CH3COCH3
CAS Number:
Molecular Weight:
58.08
Beilstein:
635680
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

vapor density

2 (vs air)

vapor pressure

184 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

expl. lim.

13.2 %

application(s)

HPLC: suitable

impurities

≤0.5% (water)

evapn. residue

<0.0002%

color

clear colorless

refractive index

n20/D 1.359 (lit.)

bp

56 °C/760 mmHg (lit.)

mp

−94 °C (lit.)

solubility

water: miscible

density

0.791 g/mL at 25 °C (lit.)

λ

H2O reference

UV absorption

λ: 330 nm Amax: 1.00
λ: 340 nm Amax: 0.10
λ: 350 nm Amax: 0.02
λ: 400 nm Amax: 0.01

suitability

suitable (pesticide analysis)

SMILES string

CC(C)=O

InChI

1S/C3H6O/c1-3(2)4/h1-2H3

InChI key

CSCPPACGZOOCGX-UHFFFAOYSA-N

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General description

Acetone is a ketone. Mixtures of TiO2 (P25) with rare earth oxides (La2O3 or Y2O3) calcined at 700°C or 650°C has been reported to efficiently photocatalyze the oxidation of acetone. Its aldol condensation in vapor-phase has been investigated over MgO promoted with alkali (Li, Na, K and Cs) or alkaline earth (Ca, Sr and Ba) metal ions. It undergoes Aldol condensation in the presence of Mg-Al layered double hydroxides (LDH) as catalysts and Cl- and/or CO32- as compensating anions to afford diacetone alcohol and mesityl oxide. Enantioselective Aldol condensation of acetone with various isatins in the presence of dipeptides (catalyst) has been described.

Application

Acetone was used in the affinity purification of modified proteins using streptavidin beads for the mass spectrometric (MS) identification of poly(ADP-ribose) polymerases (PARP) substrate proteins.
It may be used in the following studies:
  • NMR spectroscopic evaluation of glucose metabolism in biological samples (blood).
  • Preparation of 13wt% amorphous poly (lactic acid) (PLA) solution, which was required for the preparation of electrospun PLA membranes.
  • As a precursor for the synthesis of methyl isobutyl ketone (MIBK) in the presence of sulfonated graphene oxide-Pd/cordierite catalyst.
  • Synthesis of (4-hydroxymethyl-2,2-dimethyl-1,3-dioxolane), a solketal from glycerol using supercritical fluids (SCF) technology.
It may be used in the synthesis of the following acetone hydrazones:
  • 1-isopropylidene-2-methylhydrazine
  • 1-isopropylidene-2-hydroxyethylhydrazine
  • 1-isopropylidene-2-formylhydrazine
Acetone′s luminesence intensity is dependent upon the solution components . The absorption of UV light by acetone, results in its photolysis and the production of radials .

Packaging

50 L in composite drum
4, 4×4 L in PVC-coated bottle
20 L in Pure-Pac™ 2
20 L in Nowpak™
2×10 L in Nowpak™
18 L in VerSA-Flow™

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK Germany

WGK 1

Flash Point F

1.4 °F - closed cup

Flash Point C

-17.0 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Hong Jiang et al.
Current protocols in chemical biology, 4(1), 19-34 (2012-11-29)
Poly(ADP-ribose) polymerases (PARPs) play important roles in various biological processes, including DNA repair, transcriptional regulation, mitosis, and RNA processing. PARP inhibitors are in clinical trials for treating human cancers. Understanding the biological function of PARPs will be important to fully...
Saskia Kley et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 296(4), R936-R943 (2009-02-06)
Obesity is a risk factor for type 2 diabetes in cats. The risk of developing diabetes is severalfold greater for male cats than for females, even after having been neutered early in life. The purpose of this study was to...
Synthesis and characterization of acetone hydrazones.
Miro SC and Delalu H.
Zeitschrift fur Anorganische und Allgemeine Chemie, 638(1), 57-63 (2012)
Ketalization of glycerol to solketal in supercritical acetone.
Royon D, et al.
Journal of Supercritical Fluids, 58(1), 88-92 (2011)
Sulfonated graphene oxide supported Pd bifunctional catalyst for one-pot synthesis of methyl isobutyl ketone from acetone with high conversion and selectivity.
Liu M, et al.
J. Mol. Catal. A: Chem., 408, 85-90 (2015)

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