45706

Warfarin

PESTANAL^®, analytical standard

• Synonym(s): 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin, Coumafene
• Empirical Formula (Hill Notation): C₁₉H₁₆O₄
• CAS Number: 81-81-2
• Molecular Weight: 308.33
• Beilstein: 8868198
• EC Number: 201-377-6
• MDL number: MFCD00006854
• PubChem Substance ID: 329756915
• NACRES: NA.24

Properties

• Quality Level: 100
• grade: analytical standard
• product line: PESTANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 162-164 °C (lit.)
• application(s): agriculture; environmental
• format: neat
• SMILES string: CC(=O)CC(c1ccccc1)C2=C(O)c3ccccc3OC2=O
• InChI: 1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3
• InChI key: PJVWKTKQMONHTI-UHFFFAOYSA-N
• Gene Information: human ... VKORC1(79001)

Description

Application

Warfarin is an anticoagulant commonly used in the prevention of thrombosis and thromboembolism. Its use is studied in stroke and pulmonary fibrosis patients among many others. It is used to study potential risks and interactions with other drugs and food.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Warfarin consists of a racemic mixture of two active enantiomers, R- and S- forms. Warfarin is slower-acting than the common anticoagulant heparin. Warfarin inhibits the vitamin K-dependent synthesis of biologically active forms of the calcium-dependent clotting factors II, VII, IX and X. It inhibits regulatory factors protein C, protein S, and protein Z.

Caution

Restricted to professional users. Attention − Avoid exposure − obtain special instructions before use.

Legal Information

PESTANAL is a registered trademark of Sigma-Aldrich International GmbH

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330 - H360 - H372 - H411
• Precautionary Statements: P202 - P260 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Aquatic Chronic 2 - Repr. 1A - STOT RE 1 Oral
• Target Organs: Blood
• Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3