46140

Supelco

Cloxacillin sodium salt monohydrate

VETRANAL®, analytical standard

Empirical Formula (Hill Notation):
C19H17ClN3NaO5S · H2O
CAS Number:
Molecular Weight:
475.88
Beilstein/REAXYS Number:
5403885
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

analytical standard

Agency/Method

EPA 1694

product line

VETRANAL®

form

neat

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

SMILES string

O.[Na].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c3c(C)onc3-c4ccccc4Cl)C(O)=O

InChI

1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

InChI key

KCUWTKOTPIUBRI-VICXVTCVSA-M

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

pictograms

Exclamation markHealth hazard

signalword

Danger

hazcat

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 2

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificate of Analysis

Certificate of Origin

Sternoclavicular septic arthritis and empyema.
María José Moreno Martínez et al.
Reumatologia clinica, 8(2), 102-103 (2011-12-14)
Shih-Ping Lin et al.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 45(3), 200-207 (2012-01-03)
A growing number of β-lactamases have been reported in Pseudomonas aeruginosa isolates. The aims of this study were to survey the types of extended-spectrum β-lactamases (ESBLs) by polymerase chain reaction (PCR), to evaluate the reliability of phenotypic tests for ESBLs...
Felipe Cavagnaro et al.
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 30(1), 81-85 (2013-03-02)
Pyomyositis (PM) is an uncommon pyogenic infection of skeletal muscle and, when not properly treated, it can progress to a high-risk clinical situation with high mortality. Because it usually has a subacute presentation, diagnosis is often delayed. We present two...
C Garrigós et al.
Antimicrobial agents and chemotherapy, 56(7), 3806-3811 (2012-05-16)
Despite the use of daptomycin alone at high doses (greater than 6 mg/kg of body weight/day) against difficult-to-treat infections, clinical failures and resistance appeared. Recently, the combination daptomycin-cloxacillin showed enhanced efficacy in clearing bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA)....
J P Bru et al.
Medecine et maladies infectieuses, 42(6), 241-246 (2012-05-01)
One of the issues of antibiotic treatment is to warrant its optimal effectiveness while minimizing the risk for emergence of resistance. The time above minimal inhibiting concentration (MIC) (T>MIC) is the best predictive pharmacological parameter of effectiveness for antibiotics with...

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