75890

α-Ketoglutaric acid

99.0-101.0% (T)

• Synonym(s): 2-Oxoglutaric acid, alpha-Ketoglutaric acid, alpha-Ketoglutarate, 2-Oxopentanedioic acid
• Linear Formula: HOOCCH₂CH₂COCOOH
• CAS Number: 328-50-7
• Molecular Weight: 146.10
• Beilstein: 1705689
• EC Number: 206-330-3
• MDL number: MFCD00004165
• PubChem Substance ID: 329766750
• NACRES: NA.22

Properties

• Quality Level: 300
• assay: 99.0-101.0% (T)
• form: crystals
• mp: 114-118 °C
• solubility: H₂O: 1 g/10 mL, clear to slightly hazy, colorless to almost colorless
• storage temp.: 2-8°C
• SMILES string: OC(=O)CCC(=O)C(O)=O
• InChI: 1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
• InChI key: KPGXRSRHYNQIFN-UHFFFAOYSA-N

Description

General description

α-Ketoglutaric acid is a 2-oxocarboxylic acid (2-OCA) that is formed as a metabolite in the Kreb′s cycle.

Application

α-ketoglutaric acid along with L-arginine can undergo reduction with sodium cyanoborohydride to form the diastereomers, nopaline and isonopaline.

Other Notes

Reagent for the analysis of tryptophan; Substrate for glutamate dehydrogenase

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H318
• Precautionary Statements: P280 - P305 + P351 + P338 + P310
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves