Merck
  • D125806
All Photos(4)

D125806

Sigma-Aldrich

N,N-Diisopropylethylamine

ReagentPlus®, ≥99%

All Photos(4)
Synonym(s):
N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine, ‘Hünig’s base’
Linear Formula:
[(CH3)2CH]2NC2H5
CAS Number:
7087-68-5
Molecular Weight:
129.24
EC Number:
230-392-0
MDL number:
MFCD00008868
PubChem Substance ID:
329798682
NACRES:
NA.21

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N,N-Diisopropylethylamine purified by redistillation, 99.5%

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Triethylamine

≥99.5%

Propylphosphonic anhydride solution ≥50 wt. % in ethyl acetate

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≥50 wt. % in ethyl acetate

HBTU ≥98.0% (T)

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HBTU

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1-Hydroxybenzotriazole hydrate ≥97.0% dry basis (T)

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1-Hydroxybenzotriazole hydrate

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N,N-Dimethylformamide anhydrous, 99.8%

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N,N-Dimethylformamide

anhydrous, 99.8%

N,N-Diisopropylethylamine purified by redistillation, ZerO2®, 99.5%

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N,N-Diisopropylethylamine

purified by redistillation, ZerO2®, 99.5%

1,8-Diazabicyclo[5.4.0]undec-7-ene 98%

Sigma-Aldrich

139009

1,8-Diazabicyclo[5.4.0]undec-7-ene

98%

vapor pressure

31 mmHg ( 37.7 °C)

Quality Level

200

product line

ReagentPlus®

assay

≥99%

form

liquid

refractive index

n20/D 1.414 (lit.)

bp

127 °C (lit.)

mp

<−50 °C (lit.)

density

0.742 g/mL at 25 °C (lit.)

SMILES string

CCN(C(C)C)C(C)C

InChI

1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

InChI key

JGFZNNIVVJXRND-UHFFFAOYSA-N

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General description

N,N-Diisopropylethylamine, also known as Hünig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed for substitution reactions. It acts as an activator for chiral iridium N, P ligand complexes, which can be utilized in the hydrogenation of α, β-unsaturated nitriles. The influence of varying concentration of N,N-diisopropylethylamine on the synthesis of olvanil in the presence of lipase catalyst has been investigated.

Application

N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.
Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.

Packaging

100, 100, 500 mL in glass bottle
1, 2.5 L in glass bottle
10, 50 L in composite drum
5, 100, 500 g

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.1 °F

Flash Point(C)

9.5 °C

Certificate of Analysis

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Certificate of Origin

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