M9546

Sigma-Aldrich

D-Mannitol

BioXtra, ≥98% (HPLC)

Synonym(s):
Mannite
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein/REAXYS Number:
1721898
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

product line

BioXtra

assay

≥98% (HPLC)

impurities

≤0.0005% Phosphorus (P)
≤0.01% Insoluble matter

ign. residue

≤0.01%

mp

167-170 °C (lit.)

solubility

H2O: 1 M, clear, colorless

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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General description

D-Mannitol is the alcohol form of mannose. Its molar mass is 182 g/mol. Mannitol is present widely in plants, fungi and algae. It is extracted mainly from seaweeds. It is used in food for diabetic patients as it is absorbed slowly. It is commonly used as a stabilizer, humectant, nutritive sweetener and bulking agent in food.

Application

D-Mannitol has been used:
  • as a hydroxyl radical inhibitor, to detect the hydroxyl radical generation during the reactive oxygen species (ROS) modification of chromatin
  • in [3H]-mannitol permeability assay and also as a component in buffer B for measuring the transmonolayer dilution potentials
  • as a component in extracellular recording solution for whole cell patch clamp recordings

Packaging

250 g in poly bottle
1 kg in poly bottle

Biochem/physiol Actions

D-Mannitol is used as an osmotic agent for the treatment of brain swellings.
A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M9546.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 1

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Sweeteners: Nutritional Aspects, Applications, and Production Technology, 59-59 (2012)
Neurology of the Newborn, 459-459 (2008)
Methods to examine tight junction physiology in cancer stem cells: TEER, paracellular permeability, and dilution potential measurements
Buchert M, et al.
Stem Cell Reviews and Reports, 8(3), 1030-1034 (2012)
Allosteric interactions between NMDA receptor subunits shape the developmental shift in channel properties
Sun W, et al.
Neuron, 94(1), 58-64 (2017)
Antibodies against 4-hydroxy-2-nonenal modified epitopes recognized chromatin and its oxidized forms: role of chromatin, oxidized forms of chromatin and 4-hydroxy-2-nonenal modified epitopes in the etiopathogenesis of SLE
Al-Shobaili HA, et al.
Disease Markers, 33(1), 19-34 (2012)

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