PHR1000

Dextrose

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): D-(+)-Glucose, Dextrose
• Empirical Formula (Hill Notation): C₆H₁₂O₆
• CAS Number: 50-99-7
• Molecular Weight: 180.16
• Beilstein: 1724615
• EC Number: 200-075-1
• MDL number: MFCD00063774
• UNSPSC Code: 12352201
• PubChem Substance ID: 329823031
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to Ph. Eur. Y0001745; traceable to USP 1181302
• API family: dextrose
• Assay: 99.9%
• CofA: current certificate can be downloaded
• analyte chemical class(es): oligosaccharides
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 150-152 °C (lit.)
• application(s): detection; food and beverages; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChI key: WQZGKKKJIJFFOK-DVKNGEFBSA-N

Description

General description

Dextrose belongs to the class of sugars, and is a preferred source of carbohydrate in parenteral nutrition regimens. It is widely used in solutions to adjust tonicity, as a sweetening agent, wet granulation diluent/binder, direct-compression tablet diluent/binder, etc. It is considered only for short term clinical use, since it is deficient in electrolytes.[1][2]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Dextrose has been used as a standard in the determination of additives like glucose in beverages using high performance liquid chromatography (HPLC).[3] It may also be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique.[4]

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7785 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable