PHR1034

Supelco

Lidocaine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Lignocaine, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Xylocaine
Empirical Formula (Hill Notation):
C14H22N2O
CAS Number:
Molecular Weight:
234.34
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

form

neat

CofA

current certificate can be downloaded

application(s)

HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Cleaning Products
Cosmetics
Food and Beverages
Personal Care
Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to BP 727
traceable to PhEur L0595000
traceable to USP 1366002

SMILES string

CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

InChI key

NNJVILVZKWQKPM-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Lidocaine is a local anesthetic drug that can exhibit pronounced antiarrhythmic and anticonvulsant effects. It is known as a central nervous system depressant and shows sedative, analgesic and anticonvulsant properties.
Lidocaine is a drug, which serves as a potential candidate in the treatment of cardiac arrhythmias.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Lidocaine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
Lidocaine may be used as an internal standard in the determination of perhexiline in human serum samples using gas liquid chromatography (GLC).

Biochem/physiol Actions

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0142 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark

signalword

Warning

hcodes

hazcat

Acute Tox. 4 Oral

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificate of Analysis

Certificate of Origin

High-performance liquid chromatographic method for the simultaneous determination of lidocaine and its N-dealkylated metabolites in plasma
Nation.LR, et al.
Journal of Chromatography. B, Biomedical Applications, 162, 466-473 (1979)
A rapid method for the determination of perhexiline in serum using gas-liquid chromatography
CooperHDJ and Turnell CD
Annals of Clinical Biochemistry, 17, 155-158 (1980)
Stability indicating HPLC method for the estimation of oxycodone and lidocaine in rectal gel
Gebauer MG, et al.
International Journal of Pharmaceutics, 223(1-2), 49-54 (2001)
Simultaneous determination of tolperisone and lidocaine by high performance liquid chromatography
Liawruangrath S, et al.
Journal of Pharmaceutical and Biomedical Analysis, 26(5-6), 865-872 (2001)
Development and validation of RP-HPLC method for cetrimonium bromide and lidocaine determination.
Malenovic A, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(2), 157-161 (2005)
Related Content
HILIC mobile phases consist of a high composition of acetonitrile, which facilitates the direct analysis of precipitated plasma samples without the need for additional sample solvent exchange.
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The benefit of HILIC over traditional reversed-phase chromatography is two-fold for both sample introduction and analyte detection. First, the high acetonitrile concentration of HILIC mobile phases allows for direct analysis of precipitated plasma samples without the need for additional sample solvent exchange. Second, the high acetonitrile content provides increased analyte response in positive ESI MS detection.
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