PHR1045

Diethylene glycol

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): DEG, 2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol
• Linear Formula: (HOCH₂CH₂)₂O
• CAS Number: 111-46-6
• Molecular Weight: 106.12
• Beilstein: 969209
• EC Number: 203-872-2
• MDL number: MFCD00002882
• PubChem Substance ID: 329823075
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to Ph. Eur. Y0000217; traceable to USP 1193265
• vapor density: 2.14 (vs air)
• vapor pressure: 0.01 mmHg ( 20 °C)
• API family: diethylene glycol
• CofA: current certificate can be downloaded
• autoignition temp.: 442 °F
• expl. lim.: 2-12.3 %
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.447 (lit.)
• bp: 245 °C (lit.)
• mp: −10 °C (lit.)
• density: 1.118 g/mL at 25 °C (lit.)
• application(s): cleaning products; cosmetics; food and beverages; personal care; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: OCCOCCO
• InChI: 1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2
• InChI key: MTHSVFCYNBDYFN-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.

Application

Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).

Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 280.4 °F - closed cup
• Flash Point(C): 138 °C - closed cup