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Valproic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Valproic acid, 2-Propylpentanoic acid, 2-Propylvaleric acid
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


certified reference material
pharmaceutical secondary standard


traceable to Ph. Eur. V0033000
traceable to USP 1708707


current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.425 (lit.)


220 °C (lit.)


0.9 g/mL at 25 °C (lit.)


pharmaceutical (small molecule)



storage temp.


SMILES string




InChI key


Gene Information

human ... ALDH5A1(7915)

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General description

Valproic acid is a branched short chain fatty acid, which finds applications as a antiepileptic drug.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
It is widely used in the treatment of bipolar disorder, migraine, depression, epilepsy and schizophrenia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Valproic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using gas chromatography technique.

Biochem/physiol Actions

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAB3712 in the slot below. This is an example certificate only and may not be the lot that you receive.


Exclamation markHealth hazard

Signal Word


Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1A - Skin Irrit. 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects



Flash Point(F)

231.8 °F

Flash Point(C)

111 °C

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Inhibition of microsomal Phenobarbital metabolism by valproic acid
Kapetanovic MI and Kupferberg JH
Biochemical Pharmacology, 30(11), 1361-1363 (1981)
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
Phiel JC, et al.
The Journal of Biological Chemistry, 276(39), 36734-36741 (2001)
Headspace solid-phase microextraction-gas chromatography method for the determination of valproic acid in human serum, and formulations using hollow-fiber coated wire
Farajzadeh AM, et al.
Analytical Sciences, 25(7), 875-879 (2009)
P C Ho et al.
The pharmacogenomics journal, 3(6), 335-342 (2003-11-05)
The present study investigated the effect of cytochrome P450 2C9 (CYP2C9) genetic polymorphism on the biotransformation of valproic acid (VPA) to its hepatotoxic metabolite, 4-ene-VPA, and compared that to the formation of the inactive 4-OH-VPA and 5-OH-VPA. cDNA-expressed CYP2C9(*)2 and
Jiajun Zhou et al.
Journal of cellular and molecular medicine, 24(15), 8636-8649 (2020-07-01)
Chronic renal failure (CRF) is commonly associated with various adverse consequences including pathological vascular calcification (VC), which represents a significant clinical concern. Existing literature has suggested the involvement of histone deacetylases (HDACs) in the progression of CRF-induced VC. However, the

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