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Residual Solvents Mixture - Class IIA

Pharmaceutical Secondary Standard; Certified Reference Material


Quality Level


certified reference material
pharmaceutical secondary standard


current certificate can be downloaded


suitable for 467 per USP


pharmaceutical (small molecule)


multi-component solution

pharmacopeia traceability

traceable to USP 1601281

storage temp.


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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvents Mixture - Class IIA are certified reference materials (CRMs) for the analysis of residual solvents. The residual solvents can be found as mixtures, as single-analyte standards, as well as neat CRMs. These CRMs are secondary pharmaceutical reference standards and are traceable and qualified against the corresponding Pharmacopeial standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAB7797 in the slot below. This is an example certificate only and may not be the lot that you receive.



    Acetonitrile 2 mg/mL
    Chlorobenzene 2 mg/mL
    Cumene 0.3 mg/mL
    Cyclohexane 14 mg/mL
    cis-1,2-Dichloroethene 4 mg/mL
    trans-1,2-Dichloroethene 4 mg/mL
    Methylene Chloride 3 mg/mL
    1,4-Dioxane 2 mg/mL
    Methanol 15 mg/mL
    Methylcyclohexane 5 mg/mL
    Tetrahydrofuran 4 mg/mL
    Toluene 4 mg/mL
    Ethylbenzene 2 mg/mL
    p-Xylene 1 mg/mL
    m-Xylene 1 mg/mL
    o-Xylene 7 mg/mL
    See All (16)

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 3

Storage Class Code

10 - Combustible liquids



Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Certificate of Analysis

Certificate of Origin

Seung Baek Lee et al.
Nature cell biology, 21(8), 940-951 (2019-07-31)
The receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 play important roles in necroptosis that are closely linked to the inflammatory response. Although the activation of necroptosis is well characterized, the mechanism that tunes down necroptosis is largely unknown. Here we find

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