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Pharmaceutical Secondary Standard; Certified Reference Material

CAS Number:
EC Number:

Quality Level


certified reference material
pharmaceutical secondary standard


traceable to Ph. Eur. T2610000
traceable to USP 1700501


current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


pharmaceutical (small molecule)



storage temp.




InChI key


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General description

Tryptophan is an essential amino acid and a precursor for the synthesis of serotonin (5-HT), a neuromodulator responsible for modulating sleep and appetite regulation.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tryptophan may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

Values of analytes vary lot to lot.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAB2382 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

The use of carbon paste electrode in the direct voltammetric determination of tryptophan in pharmaceutical formulations
Fiorucci AR, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(5), 909-915 (2002)
Differential spectrophotometric determination of tyrosine and tryptophan in pharmaceutical amino acid solutions
Demeester J, et al.
Journal of Pharmaceutical Sciences, 67(5), 729-730 (1978)
Evolution of tryptophan and its foremost metabolites? concentrations in milk and fermented dairy products
Bertazzo A, et al.
PharmaNutrition, 4(2), 62-67 (2016)
Tryptophan supplementation modulates social behavior: a review
Steenbergen L, et al.
Neuroscience and Biobehavioral Reviews, 64, 346-358 (2016)
Saara Ahmad et al.
JPMA. The Journal of the Pakistan Medical Association, 63(1), 65-68 (2013-07-20)
To investigate the relationship between plasma tryptophan and the occurrence of memory dysfunctions in male and female type 1 diabetics. The case-control study was conducted at two urban healthcare facilities in Karachi from January to June 2009, and comprised 100


GC Analysis of Amino Acids (as TBDMS Derivatives) on SLB®-5ms (20 m x 0.18 mm I.D., 0.18 μm), Fast GC Analysis

Separation of L-Alanine; Glycine; L-Valine; L-Leucine; L-Isoleucine; L-Proline; L-Methionine; L-Serine; L-Threonine; L-Phenylalanine; L-Aspartic acid; L-4-Hydroxyproline; L-Cysteine; L-Glutamic acid; L-Asparagine; L-Lysine; L-Glutamine; L-Histidine; L-Tyrosine; L-Tryptophan; L-Cystine

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