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PHR1257

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Lidocaine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Lidocaine hydrochloride monohydrate, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate
Empirical Formula (Hill Notation):
C14H22N2O · HCl · H2O
CAS Number:
Molecular Weight:
288.81
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to BP 214
traceable to Ph. Eur. L0600000
traceable to USP 1366013

API family

lidocaine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2

InChI key

YECIFGHRMFEPJK-UHFFFAOYSA-N

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This Item
L0600000BP214PHR1673
Lidocaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

PHR1257

Lidocaine hydrochloride

Lidocaine hydrochloride European Pharmacopoeia (EP) Reference Standard

L0600000

Lidocaine hydrochloride

Lidocaine hydrochloride British Pharmacopoeia (BP) Reference Standard

BP214

Lidocaine hydrochloride

Lidocaine Related Compound H Pharmaceutical Secondary Standard; Certified Reference Material

PHR1673

Lidocaine Related Compound H

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-30°C

agency

traceable to BP 214

agency

-

agency

-

agency

traceable to USP 1366080

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Lidocaine hydrochloride is an amide type local anaesthetic that belongs to the class of 1b antiarrhythmics. It is used for regional nerve blocks and infiltrative administration of anaesthesia. It prevents the entry of sodium ions into nerve endings, at the site of pain, and disrupts the electrical signal from reaching the brain.

Application

This pharmaceutical secondary standard can also be used as follows:
  • Sensitive determination of lidocaine hydrochloride and cetylpyridinium chloride in their binary mixtures in different pharmaceutical formulations by three spectrophotometric-based methods
  • Simultaneous analysis of aminoacridine hydrochloride and lidocaine hydrochloride in bulk powder and pharmaceutical formulation by high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC)-densitometric methods
  • Quantification of ceftriaxone sodium and lidocaine HCl in human plasma samples by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS)
  • Quantitative analysis of lidocaine hydrochloride and miramistin in a wound healing gel sample by high-performance liquid chromatography (HPLC) combined with UV detection
  • Development of a method based on liquid–liquid extraction of nifedipine and lidocaine hydrochloride from human plasma samples for their subsequent analysis by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
  • Dispersive liquid-liquid microextraction (DLLME) followed by attenuated total reflectance-Fourier transform infrared measurement of dry films for the determination of lidocaine hydrochloride in human urine sample

Biochem/physiol Actions

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3669 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Lories I Bebawy et al.
Journal of chromatographic science, 54(4), 492-499 (2015-12-17)
Two sensitive and selective analytical methods were developed for simultaneous determination of aminoacridine hydrochloride and lidocaine hydrochloride in bulk powder and pharmaceutical formulation. Method A was based on HPLC separation of the cited drugs with determination of the toxic lidocaine-related
Development and Validation of a Method for Determining Lidocaine Hydrochloride and Miramistin in an Innovative Wound-Healing Gel
Brkich LL, et al.
Pharmaceutical Chemistry Journal, 54, 69-72 (2020)
George A Spirou et al.
eLife, 12 (2023-06-08)
Globular bushy cells (GBCs) of the cochlear nucleus play central roles in the temporal processing of sound. Despite investigation over many decades, fundamental questions remain about their dendrite structure, afferent innervation, and integration of synaptic inputs. Here, we use volume
Determination of lidocaine in urine at low ppm levels using dispersive microextraction and attenuated total reflectance-Fourier transform infrared measurements of dry films
Perez-Guaita D, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 121, 178-183 (2015)
Shaun Mehta et al.
JAMA facial plastic surgery, 16(6), 414-418 (2014-09-12)
This study evaluates the postoperative outcomes achieved with incisionless otoplasty for the correction of prominauris. To determine whether incisionless otoplasty is a reliable and replicable technique in correcting prominauris. This study consisted of a retrospective electronic medical record review for

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