All Photos(1)

PHR1274

Supelco

Melamine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
2,4,6-Triamino-1,3,5-triazine, sym-Triaminotriazine
Empirical Formula (Hill Notation):
C3H6N6
CAS Number:
Molecular Weight:
126.12
Beilstein:
124341
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1379183

storage temp.

2-30°C

SMILES string

Nc1nc(N)nc(N)n1

InChI

1S/C3H6N6/c4-1-7-2(5)9-3(6)8-1/h(H6,4,5,6,7,8,9)

InChI key

JDSHMPZPIAZGSV-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Melamine is a nitrogen-rich chemical employed in the production of plastics, resins, laminates, adhesives as well as flame retardants. It may also be utilized as a fertilizer. It is one of the metabolites of cyromazine, which is approved for use as an insecticide on a wide range of vegetable crops.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3464 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

572.0 °F - closed cup

Flash Point(C)

300 °C - closed cup

Certificate of Analysis

Certificate of Origin

Method development and validation for melamine and its derivatives in rice concentrates by liquid chromatography. Application to animal feed samples
Mu?iz-Valencia R, et al.
Analytical and Bioanalytical Chemistry, 392(3), 523-531 (2008)
Hui Yang et al.
Nano letters, 15(3), 1730-1735 (2015-02-11)
We detect by optical microscopy Au and fluorescent nanoparticles (NPs) during their motion in water-based medium, using an array of dielectric microspheres that are patterned in a microwell array template. The microspheres act as lenses focusing the light originating from
D Frösch et al.
Electron microscopy reviews, 2(2), 231-255 (1989-01-01)
Melamine resins are derived from the heterocyclic compound triaminotriazine, C3H6N6. Similar to proteins in structure and reactivity, water-soluble melamine resins can be used as water-embedding media for electron microscopy (Bachhuber and Frösch, 1983). The idea behind this approach was to
Vivek Bhalla et al.
Kidney international, 75(8), 774-779 (2009-02-13)
Recent outbreaks of nephrolithiasis and acute kidney injury among children in China have been linked to ingestion of milk-based infant formula contaminated with melamine. These cases provide evidence in humans for the nephrotoxicity of melamine, which previously had been described
Ana Paula Craig et al.
Annual review of food science and technology, 4, 369-380 (2013-01-10)
Surface-enhanced Raman spectroscopy (SERS) is an advanced Raman technique that enhances the vibrational spectrum of molecules adsorbed on or in the vicinity of metal particles and/or surfaces. Because of its readiness, sensitivity, and minimum sample preparation requirements, SERS is being

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