PHR1320

Residual Solvent - Acetonitrile

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Acetonitrile, ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide
• Linear Formula: CH₃CN
• CAS Number: 75-05-8
• Molecular Weight: 41.05
• Beilstein: 741857
• EC Number: 200-664-3
• MDL number: MFCD00001878
• PubChem Substance ID: 329823305
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1601340
• vapor density: 1.41 (vs air)
• vapor pressure: 72.8 mmHg ( 20 °C)
• CofA: current certificate can be downloaded
• autoignition temp.: 973 °F
• expl. lim.: 16 %
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.344 (lit.)
• bp: 81-82 °C (lit.)
• mp: −45 °C (lit.)
• density: 0.786 g/mL at 25 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: single component solution
• storage temp.: 2-30°C
• SMILES string: CC#N
• InChI: 1S/C2H3N/c1-2-3/h1H3
• InChI key: WEVYAHXRMPXWCK-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent - Acetonitrile is a CRM and Secondary Pharmaceutical Reference Standard, traceable and qualified against the corresponding Pharmacopeial standards. Sigma-Aldrich offers Fluka brand Certified Reference Materials (CRMs) for the analysis of Residual Solvents. A comprehensive Certificate of Analysis offers details of the methodology and results of the qualification.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0679 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): 188.6 °F - closed cup
• Flash Point(C): 87 °C - closed cup