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PHR1372

Supelco

Methanol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Methyl alcohol, Methanol
Linear Formula:
CH3OH
CAS Number:
Molecular Weight:
32.04
Beilstein:
1098229
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

1.11 (vs air)

vapor pressure

410 mmHg ( 50 °C)
97.68 mmHg ( 20 °C)

form

neat

CofA

current certificate can be downloaded

autoignition temp.

725 °F

expl. lim.

36 %

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.329 (lit.)

bp

64.7 °C (lit.)

mp

−98 °C (lit.)

density

0.791 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1424109

SMILES string

CO

InChI

1S/CH4O/c1-2/h2H,1H3

InChI key

OKKJLVBELUTLKV-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methanol is a widely used polar organic solvent in chemistry, biochemistry, and molecular biology. It is a common solvent in HPLC and mass spectrometry (MS) of small molecules and of biomolecules such as oligonucleotides and proteins. Methanol is also utilized in high performance capillary electrophoresis. Industrial applications of methanol include the manufacture of formaldehyde and methyl esters of organic and inorganic acids. Methanol is used as a solvent and solvent adjuvant for polymers, and as a softening agent for pyroxylin plastics.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7353 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK Germany

WGK 2

Flash Point F

49.5 °F - closed cup

Flash Point C

9.7 °C - closed cup

Certificate of Analysis

Certificate of Origin

Timo Heidt et al.
Circulation research, 115(2), 284-295 (2014-05-03)
Macrophages populate the steady-state myocardium. Previously, all macrophages were thought to arise from monocytes; however, it emerged that, in several organs, tissue-resident macrophages may self-maintain through local proliferation. Our aim was to study the contribution of monocytes to cardiac-resident macrophages...
Lakshmi Gopinathan et al.
Cancer research, 74(14), 3870-3879 (2014-05-08)
Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed...
Nicolas Vodovar et al.
European heart journal, 35(48), 3434-3441 (2014-08-27)
Increases in plasma B-type natriuretic peptide (BNP) concentrations in those with acutely decompensated heart failure (ADHF) has been mainly attributed to an increase in NPPB gene transcription. Recently, proBNP glycosylation has emerged as a potential regulatory mechanism in the production...
Panagiotis Ntziachristos et al.
Nature, 514(7523), 513-517 (2014-08-19)
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic...
B Alkhatib et al.
European cells & materials, 28, 98-110 (2014-09-13)
Excessive mechanical loading or acute trauma to intervertebral discs (IVDs) is thought to contribute to degeneration and pain. However, the exact mechanisms by which mechanical injury initiates and promotes degeneration remain unclear. This study investigates biochemical changes and extracellular matrix...

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