PHR1673

Lidocaine Related Compound H

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): N-(2,6-Dimethylphenyl)chloroacetamide, n-(2,6-Dimethylphenyl)chloroacetamide, 1-Chloroacetylamino-2,6-dimethylbenzene, 2-Chloro-2′,6′-acetoxylidide, 2-Chloro-2′,6′-dimethylacetanilide, 2-Chloro-N-(2,6-dimethylphenyl)acetamide, N-(2,6-Dimethylphenyl)-2-chloroacetamide, N-(2,6-Xylyl)chloroacetamide, N-Chloroacetyl-2,6-dimethylaniline, Chloroacetamido-2,6-xylidine
• Linear Formula: ClCH₂CONHC₆H₃(CH₃)₂
• CAS Number: 1131-01-7
• Molecular Weight: 197.66
• EC Number: 214-460-7
• MDL number: MFCD00000926
• PubChem Substance ID: 329823547
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1366080
• CofA: current certificate can be downloaded
• packaging: pkg of 100 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 150-151 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: Cc1cccc(C)c1NC(=O)CCl
• InChI: 1S/C10H12ClNO/c1-7-4-3-5-8(2)10(7)12-9(13)6-11/h3-5H,6H2,1-2H3,(H,12,13)
• InChI key: FPQQSNUTBWFFLB-UHFFFAOYSA-N

Description

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Lidocaine Related Compound H is one of the impurities of the local anesthetic lidocaine found in bulk powder and dosage forms.

Application

This pharmaceutical secondary standard can also be used as follows:

• Simultaneous estimation of lidocaine hydrochloride, tribenoside, and their related compounds in pharmaceutical formulations by high-performance liquid chromatography (HPLC) combined with a UV/Vis detector
• Multi-analysis of dexpanthenol, lidocaine hydrochloride, mepyramine maleate, and their related impurities in their combined dosage forms by high-performance liquid chromatography (HPLC)-diode array detection
• Development of an HPLC method for the estimation of three active pharmaceutical ingredients along with their impurities in a semi-solid topical formulation

Packaging

100 mg

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2078 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable